BRCA1/2 mutation carriers have a considerably increased risk to develop breast and ovarian cancer during their lifetime. There is evidence from the literature that for sporadic breast cancer disease risk and the course of disease can be significantly influenced by physical activity, nutrition and weight. The hypothesis of this 3 year, prospective randomized multicenter feasibility trial is that a structured life-style intervention program with exercise training and mediterranean diet is feasible and improves the nutritional and fitness status as well as the weight, the quality of life and stress reacting capacity.

Inclusion Criteria:

• women with proven pathogenic BRCA1/2 mutation

Exclusion Criteria:

• metastatic tumor disease
• life expectancy <3 years
• clinically limiting cardiovascular or respiratory disease
• significant orthopedic disability which prevents from participating in the exercise training
• severe concomitant disease which prevents from participating in the group interventions
• Karnofsky index <60
• VO2max >150%
• Maximal exercise capacity < 50 W
• food allergies which prevent from mediterranean diet
• vegan diet
• body mass index <15 kg/m2
• pregnancy
• insufficient knowledge of German language
• insufficient compliance
• active participation in other interventional trials
• no informed consent