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Gait and posture disorders are very common in subjects aged 65 and over, and result mainly from neuromuscular and cognitive disorders.
Many studies have shown that 1) vitamin D deficiency is very common in women aged 65 and over, 2) individuals with hypovitaminosis D have lower muscle, gait and executive performances and are more prone to fail than individuals with no hypovitaminosis D, 3) the intake of vitamin D combined or not with calcium may improve muscle strength and cognitive performance.
The investigators hypothesized that the daily intake of 2 yogurts containing 200 IU of vitamin D and 400 mg of calcium 1) can improve spatiotemporal gait parameters, posture and executive performance, 2) and that this improvement depends of the initial level of vitamin D deficiency.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Yogurt supplemented with vitamin D and calcium | Experimental | 20 participants take yogurt supplemented with vitamin D and calcium during 12 weeks |
|
| Yogurt not supplemented with vitamin D and calcium | Active Comparator | 20 participants take yogurt not supplemented with vitamin D and calcium during 12 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Yogurt supplemented with vitamin D and calcium | Dietary Supplement | The product is a yogurt containing 200 IU of vitamin D and 400 mg of calcium. Participants take 2 yogurts per day. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in spatiotemporal gait, and in particular in the variability of stride time | Stride time variability is measured with spatiotemporal analysis of walking | This outcome is assessed at baseline and 12 weeks after oral intake. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in posture | Posture is evaluated with Time Up & Go, Five Time Sit-to-Stand and posture analysis with a platform. | This outcome is assessed at baseline and 12 weeks after oral intake. |
| Change in grip strength |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier Universitaire d'Angers | Angers | Maine et Loire | 49933 | France |
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| ID | Term |
|---|---|
| D014807 | Vitamin D |
| D002118 | Calcium |
| ID | Term |
|---|---|
| D012632 | Secosteroids |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
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| Yogurt not supplemented with vitamin D and calcium | Dietary Supplement | The comparator is represented by a yogurt not supplemented with vitamin D and calcium.Participants take 2 yogurts per day. |
|
Grip strength is measured with a dynamometer.
| This outcome is assessed at baseline and 12 weeks after oral intake. |
| Change in executive performance | Executive performance is measured with Trial Making Test part B (TMT B) | This outcome is assessed at baseline and 12 weeks after oral intake. |
| Change in other cognitive scores | Executive scores are assessed with digit span test (forward and backward), Trial Making Test part A (TMT A), Stoop test and Processing Speed Index | These outcomes are assessed at baseline and 12 weeks after oral intake. |
| Change in the serum concentration of 25 OHD | This outcome is assessed with the serum concentrations of 25OHD | This outcome is assessed at baseline and 12 weeks after oral intake. |
| Compliance to intervention | Compliance is measured by the number of yogurt capsules returned | This outcome is assessed 12 weeks after oral intake. |
| D008673 |
| Metals, Alkaline Earth |
| D004602 | Elements |
| D007287 | Inorganic Chemicals |
| D008670 | Metals |
| D001779 | Blood Coagulation Factors |
| D001685 | Biological Factors |