The aim of the current study is to evaluate, in a prospective cross-over, randomized study, the effect of hyperbaric oxygen therapy (HBOT) on patients with chronic neurological deficits and cognitive impairment after anterior skull base meningioma tumor removal.

Inclusion Criteria:

• Post intracranial meningioma removal surgery 3-12 months prior to the inclusion in the study.
• All patients have to have persistent cognitive or neurological complaints regarding without noticeable improvement during the last month prior to their enrolment.
• Age 18 years or older.

Exclusion Criteria:

• Dynamic neurologic/cognitive improvement or worsening during the past month;

  • Evidence of dynamic cognitive/neurological improvement in the last month.
  • Previous brain radiotherapy and/or radiosurgery.
  • Steroids dependence
  • Seizures 1 month previous to inclusion
  • Had been treated with HBOT for any other reason 1 month prior to inclusion;
  • Have any other indication for HBOT;
  • Chest pathology incompatible with pressure changes;
  • Inner ear disease;
  • Patients suffering from claustrophobia;
  • Inability to sign written informed consent;
  • Smoking patients will not be allowed to smoke during the study and if they would not comply with this demand they will be excluded.