The medium cut-off dialysis membrane has been developed to provide a significantly extended molecular cut-off compared to conventional high-flux membranes. The medium cut-off membrane allows for a high permeability of molecules up to a molecular weight of 45 kDa and has a still limited permeability for albumin (68 kDa).

The main goal of this project is the evaluation of the new, highly porous and selective dialysis membrane (MCO-Ci 400) for the treatment of patients with end-stage renal disease in hemodialysis mode and to study its potential to improve chronic inflammation.

Inclusion Criteria:

• CKD5 ( GFR < 15ml/min/ 1.73m2)
• Dialysis treatment for ≥ 3 months
• Dialysis 3x weekly
• Vascular access by fistula or CVC
• Age > 18 and < 99 Years
• Ability to give written informed consent

Exclusion Criteria:

• Missing informed consent form
• current clinically manifested infection or within the last two weeks
• current CRP-value > 50mg/L or within the last two weeks
• Intake of any medication applied for immunosuppressive purposes
• Pregnancy or lactation
• Participation in a different interventional study