role of Vit C to Augment iron chelation with DFP or DFX in thalassemic patients.

assess safety and efficacy of Vit C to Augment iron chelation with DFP or DFX in thalassemic patients.

Inclusion Criteria:

• • Subjects with overload secondary to thalassemia major

Exclusion Criteria:

• • with HIV positive or have active HCV.

  • A history of serious immunologic hypersensitivity to any medication such as anaphylaxis or angioedema.
  • Participation in a previous investigational drug study within the 30 days preceding screening.
  • A woman of childbearing potential must have a negative serum pregnancy test at screening. She must use a medically acceptable form of birth control during the study and for a month afterwards who are pregnant or breast-feeding.
  • An inability to adhere to the designated procedures and restrictions of this protocol.