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This observational study evaluates the impact of high and low chloride containing IV fluids on administrative and clinical outcomes. The study uses a large electronic health dataset and examines patients receiving fluid replacement and resuscitation. The hypothesis is that high chloride solutions are associated with adverse outcomes as measured by administrative data and by clinical parameters.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High Chloride | Patients receiving .9% sodium choride for resuscitation | ||
| Low chloride | Patients receiving Plasmalyte for resuscitation |
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| Measure | Description | Time Frame |
|---|---|---|
| Mortality | Inpatient mortality. Expected Length of inpatient stay is approximately 7 days | Hospitalization, Expected Length of inpatient stay is approximately 7 days |
| Measure | Description | Time Frame |
|---|---|---|
| Length of Stay | inpatient hospitalization, Expected Length of inpatient stay is approximately 7 days | |
| Acute renal failure | inpatient hospitalization, Expected Length of inpatient stay is approximately 7 days |
| Measure | Description | Time Frame |
|---|---|---|
| readmission | 30, 60 and 90 day |
Inclusion Criteria:
Exclusion Criteria:
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adult patients with SIRS needing fluid replacement
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Baxter Healthcare | Deerfield | Illinois | 60015 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26370823 | Derived | Shaw AD, Schermer CR, Lobo DN, Munson SH, Khangulov V, Hayashida DK, Kellum JA. Impact of intravenous fluid composition on outcomes in patients with systemic inflammatory response syndrome. Crit Care. 2015 Sep 12;19(1):334. doi: 10.1186/s13054-015-1045-z. |
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| Infections | inpatient hospitalization, Expected Length of inpatient stay is approximately 7 days |
| dysrhythmias | inpatient hospitalization, Expected Length of inpatient stay is approximately 7 days |
| Electrolyte disorders | inpatient hospitalizationExpected Length of inpatient stay is approximately 7 days |