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| Name | Class |
|---|---|
| Centers for Disease Control and Prevention | FED |
| Loyola University | OTHER |
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This is an observation study of women with gestational diabetes. Subjects recruited undergo immediate postpartum diabetic screening prior to discharge. Post-partum screening for overt diabetes is repeated 6-12 weeks postpartum. The outcome of interest is the utility of an immediate post partum screen for overt diabetes compared to a traditional 6 week test.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Gestational diabetes | Primary cohort is women with diagnosis of gestational diabetes without evidence of overt diabetes |
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| Measure | Description | Time Frame |
|---|---|---|
| Primary outcome: sensitivity of immediate post partum screen | 2 hour fasting 75g OGTT immediately post partum. This is compared to a traditional 6 week post partum 75g OGTT for the sensitivity, positive and negative predictive value of the immediate post partum test | Immediate post partum |
| Measure | Description | Time Frame |
|---|---|---|
| Secondary outcome: physiology | A small sub-cohort of women will undergo an additional 2 hour fasting 75g OGTT in the third trimester with measurements of insulin, cytokines, lipids. | 3 time points: antepatum, immediate postpartum, 6 weeks post partum |
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Inclusion Criteria:
Exclusion Criteria:
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Primary cohort is obtained from a pregnant population at two academic medical centers.
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| Name | Affiliation | Role |
|---|---|---|
| Thaddeus Waters, MD | Loyola University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital | Cleveland | Ohio | 44106 | United States | ||
| MetroHealth Medical Center |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31820038 | Derived | Waters TP, Kim SY, Sharma AJ, Schnellinger P, Bobo JK, Woodruff RT, Cubbins LA, Haghiac M, Minium J, Presley L, Wolfe H, Hauguel-de Mouzon S, Adams W, Catalano PM. Longitudinal changes in glucose metabolism in women with gestational diabetes, from late pregnancy to the postpartum period. Diabetologia. 2020 Feb;63(2):385-394. doi: 10.1007/s00125-019-05051-0. Epub 2019 Dec 9. |
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| ID | Term |
|---|---|
| D016640 | Diabetes, Gestational |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D003920 | Diabetes Mellitus |
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Serum for measurements of insulin, markers of inflammation
| Cleveland |
| Ohio |
| 44109 |
| United States |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |