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The purpose of this study is to describe and compare the different types of diabetes that exist in people from white European and south Asian origin in the UK (United Kingdom) who are diagnosed with diabetes before they turn 30 years old. By doing this we hope to identify cases of MODY (maturity onset diabetes of the young), which is a rare genetic cause of diabetes that is frequently misdiagnosed. Identifying MODY cases is important, as the treatment may differ to conventional treatment for type 1 or type 2 diabetes.
People who meet the recruitment criteria, will be invited to attend for a single fasted 2 hour visit at our research facility. During the visit we will record details of their diabetes history as well as their general health and undertake blood and urine tests. At the end of the visit their participation will be complete. We will contact them later to discuss results of specialist blood tests and whether or not they have MODY, if they have had genetic testing performed.
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| Measure | Description | Time Frame |
|---|---|---|
| Frequency of MODY | Comparison of frequency of MODY mutations between two ethnic groups | 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of biochemical and clinical characteristics in people with MODY between each ethnic group. |
| 5 years |
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Inclusion Criteria:
Exclusion Criteria:
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People in the UK diagnosed with any type of diabetes before the age of 30 years from either white European or South Asian origin.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Nick S Oliver, MRCP | Contact | +442033311065 | nick.oliver@imperial.ac.uk | |
| Des G Johnston, FRCP, PhD | Contact | +442075942429 | d.johnston@imperial.ac.uk |
| Name | Affiliation | Role |
|---|---|---|
| Nick S Oliver, MBBS, MRCP | Imperial College London | Study Director |
| Shivani Misra, MBBS, MRCP | Imperial College London | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Imperial College Clinical Research Facility | Recruiting | London | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20499044 | Background | Shields BM, Hicks S, Shepherd MH, Colclough K, Hattersley AT, Ellard S. Maturity-onset diabetes of the young (MODY): how many cases are we missing? Diabetologia. 2010 Dec;53(12):2504-8. doi: 10.1007/s00125-010-1799-4. Epub 2010 May 25. | |
| 18301398 | Background | Murphy R, Ellard S, Hattersley AT. Clinical implications of a molecular genetic classification of monogenic beta-cell diabetes. Nat Clin Pract Endocrinol Metab. 2008 Apr;4(4):200-13. doi: 10.1038/ncpendmet0778. Epub 2008 Feb 26. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Oct 10, 2022 | |
| Unrelease | Oct 14, 2022 | |
| Release | Feb 28, 2023 | |
| Reset | Dec 1, 2023 | |
| Release | Dec 1, 2023 | |
| Reset | May 10, 2024 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Oct 10, 2022 | Oct 14, 2022 | |||
| Feb 28, 2023 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D003924 | Diabetes Mellitus, Type 2 |
| D003922 | Diabetes Mellitus, Type 1 |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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We will be collecting blood and urine samples for routine diabetes tests as well as more specialist tests that will help define what type of diabetes is present. We'll also collect DNA to look for MODY (maturity onset diabetes of the young), the genetic cause of diabetes, in some people.
| Comparison of clinical and biochemical characteristics of other subtypes of diabetes | In people phenotyped as type 1 or type 2 diabetes:
| 5 years |
| 17054605 | Background | Porter JR, Rangasami JJ, Ellard S, Gloyn AL, Shields BM, Edwards J, Anderson JM, Shaw NJ, Hattersley AT, Frayling TM, Plunkett M, Barrett TG. Asian MODY: are we missing an important diagnosis? Diabet Med. 2006 Nov;23(11):1257-60. doi: 10.1111/j.1464-5491.2006.01958.x. |
| 22218698 | Background | Shields BM, McDonald TJ, Ellard S, Campbell MJ, Hyde C, Hattersley AT. The development and validation of a clinical prediction model to determine the probability of MODY in patients with young-onset diabetes. Diabetologia. 2012 May;55(5):1265-72. doi: 10.1007/s00125-011-2418-8. Epub 2012 Jan 5. |
| Dec 1, 2023 |
| Dec 1, 2023 | May 10, 2024 |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |