Colistin Pharmacokinetics in Continuous Renal Replacement Therapy

Colistimethate and Colistin Pharmacokinetics in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy (CRRT)

The blood concentration of the antibiotic colistin is determined in patients in whom kidney function is reduced such that a renal replacement therapy is needed.

Hypothesis:no dose reduction is needed in patients undergoing continuous renal replacement therapy over 24h because colistin is sufficiently removed by this procedure.

After administration of intravenous Colistin multiple blood samples are drawn over one dosing interval on day 1, 3, and 5 of treatment.

Patients are monitored for signs of neuro- and nephrotoxicity

Inclusion Criteria:

• male or female aged 18 years or older
• hospitalised on the ICU
• gram-negative infection requiring antibiotic therapy with intravenous colistin as part of their routine medical care
• clinical necessity for continuous venovenous renal replacement therapy

Exclusion Criteria:

• History of hypersensitivity to colistin or to other polymyxins
• Personal or family history of Myasthenia Gravis