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Low rate of recruitment.
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Radiotherapy is a treatment considered standard for non melanoma skin cancer. This institution uses schemes of 4 to 6 weeks of treatment. The objective of the study is to perform radiation therapy in 1 to 2 weeks, depending on the size of the lesion.
Delineation of radiation field
Technical
Distance focus-skin Tube: 35 cm Locator: 30 and 40 cm
Sizes Tube: 2, 3 and 4 cm in diameter Finder: 6x8 cm, 8x10 cm
Energy:
80 kV 140 kv
Filter 80 kV, 2 mm Al 140 kv, 0.5 mm Copper
Current Draw: 20 mA
Dose
Clinical revisions every 5 weekly sessions, or a weekly and at the end of treatment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 30 Gy in 5 fractions of 6 Gy | Experimental | tumors ≤ 2 cm in diameter: 5 fractions of 600 cGy, once a day, five times a week - TDF: 89 |
|
| 40 Gy in 10 fractions of 4 Gy | Experimental | tumors > 2-5 cm in diameter: 10 fractions of 400 cGy, once a day, five times a week - TDF: 96 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 30 Gy in 5 fractions | Radiation | 5 fractions of 600 cGy, once a day, five times a week - TDF: 89 |
|
| Measure | Description | Time Frame |
|---|---|---|
| Rate of complete remission with hypofractionated RT schemes for NMSC. | RECIST criteria
| Second week and twelfth week after initiation of radiotherapy |
| Measure | Description | Time Frame |
|---|---|---|
| Quality of Life | EORTC QLQ-C30 | Second week and twelfth week after initiation of radiotherapy |
| Toxicity | Late Effects of Normal Tissue (LENT) SOMA Toxicity Grading and Common Terminology Criteria for Adverse Events (CTCAE) version 3.0. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ricardo A Nakamura, MD | Barretos Cancer Hospital - Fundação Pio XII | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Barretos Cancer Hospital - Fundacao Pio XII | Barretos | São Paulo | 14784400 | Brazil |
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| 40 Gy in 10 fractions | Radiation | tumors > 2-5 cm in diameter: 10 fractions of 400 cGy, once a day, five times a week - TDF: 96 |
|
|
| Second week and twelfth week after initiation of radiotherapy |