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It is required to establish an adequate definition of delayed graft function in deceased donor kidney transplantation. We attempt to compare various definitions of delayed graft function and find the definition that can predict graft function survival best in deceased donor kidney transplantation.
Delayed graft function after kidney transplantation has been reported to be an important predictor for poor short and long-term survival. Delayed graft function increases post-transplantation morbidity, hospital stay, and incidence of premature graft failure. However, the definition of delayed graft function varies and more than ten definitions have been used in previous studies. Although the definition using dialysis requirements during seven days after transplantation has been used most frequently, dialysis may be required without any evidence of renal damage during one week after transplantation. Furthermore, the incidence of delayed graft function in living donor kidney transplantation using this definition has been reported to be relatively low (as low as 1.6%) compared with the incidence in deceased donor kidney transplantation (up to 50%). Therefore, it is required to establish a better definition of delayed graft function in deceased donor kidney transplantation. We attempt to compare various definitions of delayed graft function in deceased donor kidney transplantation and find the definition that can predict graft function survival best in deceased donor kidney transplantation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| patients who underwent kidney transplantation | patients who underwent living or deceased donor kidney transplantation between 2008 and 2013 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| kidney transplantation, living or deceased donor | Procedure |
|
| Measure | Description | Time Frame |
|---|---|---|
| delayed graft function as defined by dialysis requirements within one week after transplantation | delayed graft function as defined by dialysis requirements within one week after transplantation | during 7 days after transplantation |
| Measure | Description | Time Frame |
|---|---|---|
| delayed graft function as defined by urine output less than1200 ml during first day after transplantation | delayed graft function as defined by urine output less than1200 ml during first day after transplantation | during 24 hours after transplantation |
| delayed graft function as defined by serum creatinine decrease less than 10% during 48 hours after transplantation |
| Measure | Description | Time Frame |
|---|---|---|
| graft survival | graft survival one month, six month, and one year after transplantation | one month, six month, and one year after transplantation |
| Mortality | Mortality after one month, six month, and one year after transplantation |
Inclusion Criteria:
Exclusion Criteria:
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patients who underwent living or deceased donor kidney transplantation between 2008 and 2013
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Samsung Medical Center | Seoul | 135-710 | South Korea |
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| ID | Term |
|---|---|
| D051799 | Delayed Graft Function |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D016030 | Kidney Transplantation |
| ID | Term |
|---|---|
| D017582 | Renal Replacement Therapy |
| D013812 | Therapeutics |
| D016377 | Organ Transplantation |
| D014180 | Transplantation |
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delayed graft function as defined by serum creatinine decrease less than 10% during 48 hours after transplantation |
| during 48 hours after transplantation |
| delayed graft function as defined by creatinine greater than 2.5 mg/dL at ten days after transplantation | delayed graft function as defined by creatinine greater than 2.5 mg/dL at ten days after transplantation | after ten days after transplantation |
| delayed graft function as defined by creatinine clearance less than 10 ml/min/1.73m2 during 24 hours after transplantation | delayed graft function as defined by creatinine clearance less than 10 ml/min/1.73m2 during 24 hours after transplantation | during 24 hours after transplantation |
| delayed graft function as defined by creatinine did not decrease less than preoperative value | delayed graft function as defined by creatinine did not decrease less than preoperative value | during one week after transplantation |
| one month, six month, and one year after transplantation |
| immediate graft function | immediate graft function after eight days after transplantation (defined as serum creatinine decrease less than 70% of preoperative value) | after eight days after transplantation |
| slow graft function | slow graft function at eight days after transplantation (defined as serum creatinine greater than 70% of preoperative value) | at eight days after transplantation |
| D013514 |
| Surgical Procedures, Operative |
| D013520 | Urologic Surgical Procedures |
| D013519 | Urogenital Surgical Procedures |