18F-AV-1451 and Florbetapir F 18 PET (Positron Emission Tomography) Imaging in Subjects at Risk for Chronic Traumatic Encephalopathy

18F-AV-1451 and Florbetapir F 18 PET Imaging in Subjects With Repetitive Brain Trauma at High Risk for Chronic Traumatic Encephalopathy

This study will explore the use of flortaucipir as a biomarker for chronic traumatic encephalopathy (CTE) and examine the relationship between clinical presentation and tau deposition.

Inclusion Criteria:

• Male subjects consented and currently enrolled in the Diagnosing and Evaluating Traumatic Encephalopathy Using Clinical Tests (DETECT) or the Long-Term Consequences of Repetitive Brain Injury in Athletes study protocols
• Can tolerate up to two PET imaging sessions
• Have the ability to provide informed consent for study procedures

Exclusion Criteria:

• Claustrophobia
• Current clinically significant cardiovascular disease or clinically significant abnormalities on screening ECG
• History of risk factors for Torsades de Pointes or are taking drugs known to cause QT-prolongation
• Current clinically significant infectious disease, endocrine or metabolic disease, pulmonary, renal or hepatic impairment, or cancer that the investigator believes would affect study participation or scan results
• Have had a non-study related radiopharmaceutical imaging or treatment within 7 days prior to study PET imaging sessions