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| ID | Type | Description | Link |
|---|---|---|---|
| R03AG045081 | U.S. NIH Grant/Contract | View source |
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Funding ended
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| Name | Class |
|---|---|
| National Institute on Aging (NIA) | NIH |
| American College of Rheumatology Research and Education Foundation | OTHER |
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This study will evaluate if the combination of resistance exercise and protein supplementation will increase muscle strength and muscle mass among older individuals with rheumatoid arthritis (RA).
This study proposes a randomized trial to evaluate a tailored 16-week resistance exercise program, in combination with protein supplementation, for older individuals with RA. The exercise protocol in this study is distinctive because it combines dynamic and isometric (static) resistance exercise performed on specialized equipment that can accommodate the range of motion limitations frequently encountered in the older RA population. This study will also begin to evaluate if additional benefit can be achieved with daily protein supplementation
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Carbohydrate supplement | Placebo Comparator | Participants will be enrolled in a twice weekly resistance exercise program. They will receive a carbohydrate supplement to take twice daily (once after exercise). |
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| Protein Supplementation | Experimental | Participants will be enrolled in a twice weekly resistance exercise program. They will receive a twice daily protein supplement (once after exercise). |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Protein | Dietary Supplement | whey protein plus casein protein |
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| Measure | Description | Time Frame |
|---|---|---|
| Body composition | measured by dual-energy X-ray absorptiometry (DEXA) (lean mass vs fat mass) | after 16 weeks |
| Muscle strength | measured by hand grip and biodex | after 16 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Rebecca L. Manno, MD, MHS | Johns Hopkins University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Johns Hopkins Bayview Campus | Baltimore | Maryland | 21224 | United States |
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| ID | Term |
|---|---|
| D001172 | Arthritis, Rheumatoid |
| ID | Term |
|---|---|
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
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| ID | Term |
|---|---|
| D011506 | Proteins |
| D000067816 | Whey Proteins |
| D002241 | Carbohydrates |
| ID | Term |
|---|---|
| D000602 | Amino Acids, Peptides, and Proteins |
| D008894 | Milk Proteins |
| D000080224 | Animal Proteins, Dietary |
| D004044 | Dietary Proteins |
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| Carbohydrate (Placebo) | Dietary Supplement | The twice daily placebo will consist of a carbohydrate and a small amount of protein |
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| Resistance Exercise Program | Other | All participants will be enrolled in an individually supervised twice weekly (for 16 weeks) resistance exercise program |
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| D003240 |
| Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D000067796 | Whey |
| D008892 | Milk |
| D003611 | Dairy Products |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |