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To improve the treatment outcome in patients with tuberculosis and integrate the pharmacogenetics into clinical practice, the information of NAT2 genotyping was used in re-challenge protocol for isoniazid (INH) titration in patients with anti-tuberculosis medication-induced hepatitis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| isoniazid rechalleng | Experimental | When patients encountered hepatotoxicity during the anti-TB treatment, genotyping and pk study of INH would be performed and dose adjustment accordingly. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| isoniazid | Drug | dose adjustment according to the pharmacogenomic results |
|
| Measure | Description | Time Frame |
|---|---|---|
| successful re-use of isoniazid for TB treatment | In this study, we would like to test the hypothesis of NAT2 genotyping helping in isoniazid rechallenge after patients experienced adverse effects of anti-TB treatment. Therefore, to observe the patients can re-use isoniazid successfully is an important outcome measure in this study. | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
1.Taking INH before liver function abnormalities. 2.
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Li-Jiuan Shen, Ph.D. | Contact | ljshen@ntu.edu.tw |
| Name | Affiliation | Role |
|---|---|---|
| Shen Li Jiuan, Ph.D | Nationa Taiwan University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Taiwan University Hospital | Recruiting | Taipei | Taiwan |
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| ID | Term |
|---|---|
| D007538 | Isoniazid |
| ID | Term |
|---|---|
| D006834 | Hydrazines |
| D009930 | Organic Chemicals |
| D007539 | Isonicotinic Acids |
| D000147 | Acids, Heterocyclic |
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| D006571 |
| Heterocyclic Compounds |
| D011725 | Pyridines |
| D006573 | Heterocyclic Compounds, 1-Ring |