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The purpose of this non-interventional study is to collect data on the efficiency and safety of pomalidomide in combination with dexamethasone in the routine application
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pomalidomide following lenalidomide | 75 patients with pomalidomide directly following lenalidomide treatment | ||
| Pomalidomide following other therapy | 75 patients with pomalidomide following any other prior therapy. This includes lenalidomide in earlier lines than the most recent line. |
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| Measure | Description | Time Frame |
|---|---|---|
| Progression free survival (PFS) | 6 years |
| Measure | Description | Time Frame |
|---|---|---|
| Overall Response Rate (ORR) | 6 years | |
| Time to Treatment Discontinuation (TTD) | 6 years | |
| Time to next treatment (TNT) |
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Inclusion Criteria:
Exclusion Criteria:
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Adult patients with relapsing or refractory multiple myeloma previously treated with at least two prior lines of therapy, including bortezomib and lenalidomide who have progressed under their last therapy regimen
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| Name | Affiliation | Role |
|---|---|---|
| Tobias Dechow, PhD | practice based oncology office Ravensburg | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| iOMEDICO AG | Freiburg im Breisgau | Baden-Wurttemberg | 79106 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34714555 | Derived | Dechow T, Aldaoud A, Behlendorf T, Knauf W, Eschenburg H, Groschek M, Hansen R, Soling U, Grebhardt S, Siebenbach HU, Vannier C, Potthoff K. Pomalidomide plus dexamethasone for patients with relapsed or refractory multiple myeloma: Final results of the non-interventional study POSEIDON and comparison with the pivotal phase 3 clinical trials. Eur J Haematol. 2022 Feb;108(2):133-144. doi: 10.1111/ejh.13719. Epub 2021 Nov 15. |
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| ID | Term |
|---|---|
| D009101 | Multiple Myeloma |
| D009362 | Neoplasm Metastasis |
| ID | Term |
|---|---|
| D054219 | Neoplasms, Plasma Cell |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D020141 | Hemostatic Disorders |
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| 6 years |
| adverse reaction profile | 3 years |
| secondary malignancies | long term safety is focused on secondary malignancies | 6 years |
| overall Survival (OS) | 6 years |
| relative dose intensity of pomalidomide and dexamethasone | 3 years |
| assess changes in myeloma-related quality of life | 3 years |
| explore additional supportive therapies | To explore additional supportive therapies used on this patient population (e.g. G-CSF, antibiotics, DVT prophylaxis) | 3 years |
| D014652 |
| Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D010265 | Paraproteinemias |
| D001796 | Blood Protein Disorders |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D006474 | Hemorrhagic Disorders |
| D008232 | Lymphoproliferative Disorders |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |
| D009385 | Neoplastic Processes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |