Effects of Preoperative Dexamethasone Study on QOL After Vaginal Reconstructive Surgery for POP

Effects of Preoperative Dexamethasone on Postoperative Quality of Recovery Following Vaginal Reconstructive Surgery: A Randomized Controlled Trial

The investigators hypothesize that preoperative administration of 8 mg IV dexamethasone will benefit patients' perceived quality of recovery after surgery.

This is a randomized controlled trial involving single administration of 8 mg Dexamethasone per IV preoperatively among women undergoing vaginal reconstructive surgery for pelvic organ prolapse.

Inclusion Criteria:

• Women aged 18-81 years old who are scheduled to undergo a major vaginal reconstructive surgery, including hysterectomy with or without hysterectomy

Exclusion Criteria:

• Daily use of steroids or antiemetic agents such as Zofran, Reglan, Compazine and Phenargan within one month of surgery
• Regional anesthesia for surgical procedure
• Chronic pain requiring opioid treatment daily
• History of allergy to the study medication
• Severe renal and liver disease
• Pregnancy
• Non English speaking
• Psychiatric disorder that will preclude completion of questionnaires
• Minor surgery that does not involve overnight admission
• Surgery that does not involve hysterectomy or vaginal intraperitoneal apical suspension
• Hypersensitivity reaction to steroids
• Evidence of systemic fungal infection
• Evidence of any systemic infection
• Uncontrolled diabetes