Pomegranate to Reduce Maternal and Fetal Oxidative Stress and to Improve Outcome in Pregnancies Complicated With Preterm Premature Rupture of Membranes

Pomegranate to Reduce Maternal and Fetal Oxidative Stress and to Improve Outcome in Pregnancies Complicated With Preterm Premature Rupture of Membranes

Preterm premature rupture of membrane is associated with increased oxidative stress and inflammatory process, enhancing the activity or the availability of antioxidants may modulate the inflammatory response associated with PPROM, thereby reducing oxidative stress and the risk to the fetus. In this study the investigators sought to determine the effects of Pomegranate 1. On the patients (maternal and fetal) oxidative stress and inflammation associated with PPROM. 2. On the time interval from PPROM to delivery and on the patients (fetal )Ph and apger scores

In this study the investigators sought to determine the effects of Pomegranate 1. On the patients (maternal and fetal )oxidative stress and inflammation associated with PPROM. 2. On the time interval from PPROM to delivery and on the patients (fetal )Ph and apger scores

Inclusion Criteria:

• Pregnant patients
• admitted with PPROM
• between 24-32 weeks of gestation

Exclusion Criteria:

• Women with contractions
• abruption
• monochorionic multiple pregnancy
• abnormal (non-reassuring) cardiotocogram
• meconium-stained amniotic fluid
• signs of intrauterine infection
• major fetal anomalies
• hemolysis
• elevated liver enzymes
• low platelets (HELLP syndrome); or severe preeclampsia.