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Preterm premature rupture of membrane is associated with increased oxidative stress and inflammatory process, enhancing the activity or the availability of antioxidants may modulate the inflammatory response associated with PPROM, thereby reducing oxidative stress and the risk to the fetus. In this study the investigators sought to determine the effects of Pomegranate 1. On the patients (maternal and fetal) oxidative stress and inflammation associated with PPROM. 2. On the time interval from PPROM to delivery and on the patients (fetal )Ph and apger scores
In this study the investigators sought to determine the effects of Pomegranate 1. On the patients (maternal and fetal )oxidative stress and inflammation associated with PPROM. 2. On the time interval from PPROM to delivery and on the patients (fetal )Ph and apger scores
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pomegranate | Experimental | The women in this group will drink pomegranate juice |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| pomegranate | Dietary Supplement |
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| Measure | Description | Time Frame |
|---|---|---|
| Maternal and fetal oxidative stress | Maternal and fetal oxidative stress will be determined by blood tests. | 10 weeks |
| Maternal and fetal oxidative stress | Maternal blood and umbilical cord blodd will be drawn following delivery and oxidative blood markers inflammatory mediators will be assessed | 10 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Time interval from PPROM to delivery | Time interval from PPROM to delivery, respiratory distress syndrome (RDS), meconium aspiration syndrome, asphyxia, late onset neonatal sepsis, hypoglycemia, necrotizing enterocolitis, hyperbilirubinemia, intraventricular hemorrhage, periventricular leucomalacia, convulsions, other neurological abnormalities, other complications, intrapartum death, total length of hospital stay and admission, and length of stay on neonatal intensive care unit (NICU). |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| ron beloosesky, M.D | Contact | 011972509205759 | tomor2304@yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| ron beloosesky | Hillel Yaffe Medical center technion | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hillel Yaffe Medical Center | Hadera | 38100 | Israel |
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| ID | Term |
|---|---|
| C563032 | Preterm Premature Rupture of the Membranes |
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| 10 weeks |
| time interval from PPROM to delivery | following birth the time interval from PPROM to delivey will be assessed, also RDS, fetal Ph and other neonatal complications | 10 weeks |