The Immunomodulation Effect of Blood Transfusion in Operative Spine Surgery Patients

The Immunomodulation Effect of Blood Transfusion in Operative Spine Surgery Patients

The purpose of this study is to investigate the effect of transfusion of allogeneic (homologous) red cells on the immunologic parameters such as T-cells as well as natural killer cell count/function, various interleukins, TNF alpha and other immunologic relevant parameters on postoperative day 1,3 and 5-7 in patients undergoing spine surgery.

Inclusion Criteria:

• Age > 18 - < 60 years
• Patients underwent elective spine surgery
• ASA classification 1-3

Exclusion Criteria:

• Patients who have the concomitant condition
• Cancer
• History of heart disease including, heart failure, coronary artery disease, hypertension treated with more than one medicament.
• Serum creatinine > 1.5 mg/dL
• Stroke, neurologic and mental deficits, epilepsy
• General or local infection (site of surgery),
• Coagulation disorders.
• Intraoperative massive bleeding
• Infection of the spine
• Rheumatoid arthritis
• Patients who had either of the following drug (aspirin, methotrexate, cyclosporine, qualaquin)