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The purpose of this study is to compare the measure of the CO2 obtained on the end-tidal expiratory gas (ETCO2) with the value of CO2 obtained by transcutaneous measure (PTCO2), in home-ventilated neuromuscular patients.
Monitoring of the effectiveness of ventilation in patients with neuromuscular require to regularly measure blood gases and in particular carbon dioxide (CO2). The reference technique is arterial puncture. In recent years, a non-invasive techniques measuring CO2 by transcutaneous sensor (PTCO2) was introduced among the tools regularly used for follow-up monitoring of home ventilated patients.
Another technique for monitoring CO2, originally developed for anesthesia, is based on the measurement of exhaled CO2 (ETCO2). This technique requires relatively simple equipment, and represents a potential alternative for monitoring home-ventilated patients.
Recently, sensors for ETCO2 were coupled to devices for home ventilation. To the best of our knowledge, the role of ETCO2 in monitoring long-term ventilated patients has not been investigated to date.
The purpose of the study is to analyze the correlation between the two non-invasive methods for measuring CO2: PTCO2 and ETCO2, in a group of home-ventilated patients with neuromuscular disease.
The patients will be recruited during a routine follow-up hospitalization for their home-ventilation, and the ETCO2 will be measured during one night, in addition to the routinely measured PTCO2.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Monitoring of ETCO2 and PTCO2 | All neuromuscular patients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Monitoring of ETCO2 and PTCO2 | Device | Concomitant monitoring of ETCO2 and PTCO2 |
|
| Measure | Description | Time Frame |
|---|---|---|
| concordance between the nocturnal average values of ETCO2 and PTCO2 | concordance between the nocturnal average values of the CO2 measured by the two non-invasive techniques ETCO2 and PTCO2 | one night |
| Measure | Description | Time Frame |
|---|---|---|
| concordance between the nocturnal maximal values of ETCO2 and PTCO2 | concordance between the nocturnal maximal values of the CO2 measured by the two non-invasive techniques ETCO2 and PTCO2 | one night |
| concordance between the variation of the values of ETCO2 and PTCO2 |
| Measure | Description | Time Frame |
|---|---|---|
| influence of circuit leakage on the gradient between PaCO2 and ETCO2 | evaluate the influence of circuit leakage on the gradient between PaCO2 and ETCO2 | one night |
Inclusion Criteria:
Exclusion Criteria:
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The patients will be recruited among the neuromuscular patients treated at the University Hospital Raymond Pointcaré, Garches (France), during a routine follow-up hospitalization for their home-ventilation.
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| Name | Affiliation | Role |
|---|---|---|
| Adam OGNA, MD | HOPITAL RAYMOND POINCARE | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hopital Raymond Poincare | Garches | Garches | 92380 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27492508 | Derived | Orlikowski D, Prigent H, Ambrosi X, Vaugier I, Pottier S, Annane D, Lofaso F, Ogna A. Comparison of ventilator-integrated end-tidal CO2 and transcutaneous CO2 monitoring in home-ventilated neuromuscular patients. Respir Med. 2016 Aug;117:7-13. doi: 10.1016/j.rmed.2016.05.022. Epub 2016 May 24. |
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| ID | Term |
|---|---|
| D009468 | Neuromuscular Diseases |
| ID | Term |
|---|---|
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D001785 | Blood Gas Monitoring, Transcutaneous |
| ID | Term |
|---|---|
| D010092 | Oximetry |
| D001784 | Blood Gas Analysis |
| D001774 | Blood Chemical Analysis |
| D019963 | Clinical Chemistry Tests |
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concordance between the variation of the values of the CO2 measured by the two non-invasive techniques ETCO2 and PTCO2 |
| one night |
| concordance between the values of ETCO2, PTCO2 and arterial CO2 (PaCO2) measured at the same time | concordance between the values of ETCO2, PTCO2 and arterial CO2 (PaCO2) measured at the same time | one night |
| D019411 |
| Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D006334 | Heart Function Tests |
| D003935 | Diagnostic Techniques, Cardiovascular |
| D012129 | Respiratory Function Tests |
| D003948 | Diagnostic Techniques, Respiratory System |
| D008919 | Investigative Techniques |