The purpose of this study is to evaluate the usefulness of plasma 1,5-anhydro-D-glucitol (1,5-AG) as a novel surrogate marker of hypoglycemia

We enrolled well controlled diabetes patients who had hypoglycemic event at least one time more. All patients assess the risk of severe hypoglycemia and hypoglycemic unawareness using hypoglycemic awareness questionnaires (HYPO score). The patients who are treated with insulin agent were inserted sensor of continuous glucose monitoring systems under the skin during three days. We were analysed the correlation between 1,5-anhydro-D-glucitol and HYPO score.

Inclusion Criteria:

• patients attending outpatients of department of endocrinology and metabolism, seoul national university hospital .(HbA1C <8%)
• The patients who treated with insulin or sulfonylureas at least 3month period
• In case fo sulfonylurea user, HbA1c was restricted under 8%
• The patients who had hypoglycemic event at least 3 months
• who has can be survey questionnaire
• who can insert continuous glucose monitoring system

Exclusion Criteria:

• renal dysfunction patients
• hepatic dysfunction patients
• who has any kind of diseases, operations, medical treatments that can affect glucose levels

primary care clinic