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Both intravenous and oral acetaminophen have been shown to reduce post-operative pain scores when given preoperatively. This study investigates if there is a difference between the intravenous and the oral forms when given preoperatively to patients undergoing lumbar microdiscectomy. We hypothesize that the intravenous formulation does not improve pain scores or decrease opioid consumption during the first postoperative day compared to the oral formulation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| oral acetaminophen | Active Comparator | Patients in this arm of the study will receive oral acetaminophen and an IV placebo |
|
| intravenous acetaminophen | Active Comparator | Patients in this arm of the study will receive IV acetaminophen and an oral placebo |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| oral acetaminophen | Drug | 1000 milligrams given orally before surgery |
|
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative pain scores | Pain scores are measured using a visual analog scale with patient at rest and also with movement of the lower extremities at four separate times following surgery. | Day of surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Quantity of intraoperative and postoperative opioids administered. | All doses of opioids given on the day of surgery will be recorded. | Day of surgery |
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Inclusion Criteria:
Exclusion Criteria
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Marc D Fisicaro, MD | Contact | 215-955-6161 | marc.fisicaro@jefferson.edu |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Thomas Jefferson University Hopsital | Recruiting | Philadelphia | Pennsylvania | 19107 | United States |
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| ID | Term |
|---|---|
| D010146 | Pain |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D000082 | Acetaminophen |
| ID | Term |
|---|---|
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 |
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| intravenous acetaminophen | Drug | 1000 milligrams of intravenous acetaminophen given before surgery |
|
|
| Aniline Compounds |
| D000588 | Amines |