The Effect of Ebastine/Pseudoephedrine on Subacute Cough

The Effect of Ebastine/Pseudoephedrine on Subacute Cough :a Randomized Placebo-controlled Trial

To determine whether ebastine/pseudoephedrine is effective on subacute cough.

1. Visit 0 week

   • Patients with subacute cough,area randomized to either ebastine/pseudoephedrine or placebo for 1 week.
   • The cough severity and quality of life were measure with VAS score and cough-specific quality-of-life questionnaire(CQLQ)

2. Visit 1 week check VAS score and CQLQ

3. Visit 4 weeks check VAS score and CQLQ

Inclusion Criteria:

• patients with subacute cough(3-8 weeks)
• age: 20-70 years

Exclusion Criteria:

• Chest X-ray abnormality(+) as a probable cause of cough

• other explainable confirmed diagnosis(+) such as acute infectious disease

• Severe cough or cough complication which needs other anti-tussive agents.

• on ACEI

• with more than three hypertensive agents

• change of hypertension medication 3 months ago

• immunocompromized host

• relative or absolute contraindication for ebastine/pseudoephedrine

  1. hypersensitivity to ebastine/pseudoephedrine
  2. glaucoma
  3. moderate to severe hypertensive disease
  4. coronary heart disease
  5. hyperthyroidism
  6. moderate to severe liver disease
  7. benign prostate hyperplasia
  8. psychological problem
  9. Parkinson's disease
  10. on linezolid or supposed to use it.