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| Name | Class |
|---|---|
| Newcastle University | OTHER |
| Wellcome Trust | OTHER |
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Little is currently known as to the predictive value of ultrasound in guiding the decision to taper drug treatment in patients with stable rheumatoid arthritis, nor the influence that patients' views and opinions regarding their medications may have upon this. In this study, patients with stable rheumatoid arthritis will undergo a simple examination of their joints to look for any swelling or tenderness followed by an ultrasound scan to look for joint inflammation. Half of the patients will also complete an interview to assess their views and opinions of arthritis drug treatment. The study will be completed in a single patient visit - no invasive tests will be performed, and no changes to treatment will be made.
This study is being conducted as part of a Masters degree from Newcastle University. The results of this study will be used to inform the feasibility of inclusion of ultrasound assessment within the design of a future PhD study to investigate potential markers of remission in patients with rheumatoid arthritis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Observational study group | Musculoskeletal ultrasound (all patients) and semi-structured patient interview (anticipated maximum 15 patients) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Musculoskeletal Ultrasound | Other | 7-joint musculoskeletal ultrasound scan |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Evidence of reliability of intra- and inter-rater ultrasound agreement for power Doppler synovitis score | Defined as Kappa statistic of at least 0.4. | At recruitment |
| Measure | Description | Time Frame |
|---|---|---|
| Qualitative data relating to patients' views and opinions of their arthritis medication | Based upon data collected by a semi-structured interview approach and analysed using standard qualitative techniques. | At recruitment |
| Simplified Disease Activity Index (SDAI) |
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Inclusion Criteria:
Exclusion Criteria:
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Secondary care rheumatology outpatient clinic
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| Name | Affiliation | Role |
|---|---|---|
| John D Isaacs, PhD, MB BS | Newcastle University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Musculoskeletal Outpatient Department, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust | Newcastle upon Tyne | NE7 7DN | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31225429 | Derived | Baker KF, Isaacs JD, Thompson B. "Living a normal life": a qualitative study of patients' views of medication withdrawal in rheumatoid arthritis. BMC Rheumatol. 2019 Jun 13;3:2. doi: 10.1186/s41927-019-0070-y. eCollection 2019. |
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| ID | Term |
|---|---|
| D001172 | Arthritis, Rheumatoid |
| ID | Term |
|---|---|
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
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| Semi-structured patient interview |
| Other |
Semi-structured patient interview |
|
| At recruitment |
| Disease Activity Score in 28 joints (DAS-28) | At recruitment |
| Disease Activity Score (DAS) | At recruitment |
| D003240 |
| Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |