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| Name | Class |
|---|---|
| Fondazione IRCCS Policlinico San Matteo di Pavia | OTHER |
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First of all to evaluate the relationship between non-conventional biomarkers and essential hypertension; then to evaluate the effects of various anti-hypertensive drugs on blood pressure control and non-conventional biomarkers in naive hypertensive patients
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hypertensive patients | Hypertensive patients naive to hypertensive treatment |
| |
| healthy subjects | healthy subjects |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Anti-hypertensive drugs | Drug |
|
| Measure | Description | Time Frame |
|---|---|---|
| Blood pressure reduction |
| 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| Cardiovascular and metabolic biomarkers |
| 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of vascular stiffness | - Aortic Pulse Wave velocity (PWV) | 5 years |
Inclusion Criteria:
Exclusion Criteria:
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Patients with naive essential hypertension aged < 65 years without previous cardiovascular events
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Giuseppe Derosa, MD, PhD | Contact | +39 0382 502614 | giuseppe.derosa@unipv.it | |
| Amedeo Mugellini, MD, PhD | Contact | +39 0382 502614 | amedeo.mugellini@unipv.it |
| Name | Affiliation | Role |
|---|---|---|
| Giuseppe Derosa, MD, PhD | University of Pavia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| IRCCS Policlinico S.Matteo Foundation | Recruiting | Pavia | 27100 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27068332 | Derived | Derosa G, Mugellini A, Pesce RM, D'Angelo A, Maffioli P. Barnidipine compared to lercanidipine in addition to losartan on endothelial damage and oxidative stress parameters in patients with hypertension and type 2 diabetes mellitus. BMC Cardiovasc Disord. 2016 Apr 12;16:66. doi: 10.1186/s12872-016-0237-z. | |
| 26407654 | Derived |
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| ID | Term |
|---|---|
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D000959 | Antihypertensive Agents |
| ID | Term |
|---|---|
| D002317 | Cardiovascular Agents |
| D045506 | Therapeutic Uses |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
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| Derosa G, Mugellini A, Pesce RM, D'Angelo A, Maffioli P. Perindopril and barnidipine alone or combined with simvastatin on hepatic steatosis and inflammatory parameters in hypertensive patients. Eur J Pharmacol. 2015 Nov 5;766:31-6. doi: 10.1016/j.ejphar.2015.09.030. Epub 2015 Sep 25. |
| 26243165 | Derived | Derosa G, Mugellini A, Querci F, Franzetti I, Pesce RM, D'Angelo A, Maffioli P. Barnidipine or Lercanidipine on Echocardiographic Parameters in Hypertensive, Type 2 Diabetics with Left Ventricular Hypertrophy: A Randomized Clinical Trial. Sci Rep. 2015 Aug 5;5:12603. doi: 10.1038/srep12603. |
| 26223257 | Derived | Derosa G, Mugellini A, Pesce RM, D'Angelo A, Maffioli P. A study about the relevance of adding acetylsalicylic acid in primary prevention in subjects with type 2 diabetes mellitus: effects on some new emerging biomarkers of cardiovascular risk. Cardiovasc Diabetol. 2015 Jul 30;14:95. doi: 10.1186/s12933-015-0254-8. |
| 25319120 | Derived | Derosa G, Romano D, Bianchi L, D'Angelo A, Maffioli P. The effects of canrenone on inflammatory markers in patients with metabolic syndrome. Ann Med. 2015 Feb;47(1):47-52. doi: 10.3109/07853890.2014.969303. Epub 2014 Oct 16. |