Association Between Confocal Laser Endomicroscopic (CLE) Features and Gastric Mucosal Microbiome

Association Between Confocal Laser Endomicroscopic (CLE) Features and Gastric Mucosal Microbiome

There might be a correlation between gastric mucosal microbiome and mucosal pattern visualized by confocal laser endomicroscope.

The gastric mucosal microbiome plays a pivotal role in a series of diseases, such as the H.pylori infection. We hypothesized that mucosal patterns, here visualized by confocal endomicroscopy, may constitute specific microbiome niches.

Inclusion criteria:

• Patients scheduled for gastroendoscopy examination
• Aged between 18 and 80 years old

Exclusion criteria:

• Antibiotic, probiotic or prebiotic usage within 2months
• Esophageal, gastric or duodenal cancer or other malignancy
• History of upper GI tract surgery
• Coagulopathy or bleeding disorders
• Allergy to fluorescein sodium
• Pregnant or breast-feeding (for females)
• Impaired renal function