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| Name | Class |
|---|---|
| Wellcome Trust | OTHER |
| National Institute for Health Research, United Kingdom | OTHER_GOV |
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Autoimmune diseases are diseases in which inappropriate immune responses that have the capability of harming host cells play an important role. Evidence suggests that the presence of certain autoimmune diseases such as rheumatoid arthritis or systematic lupus erythematosus increase the risk of cardiovascular disease (CVD). However, this evidence is inconsistent for autoimmune disorders and no systematic approach has been previously used to study the relationship between a range of common autoimmune disorders and specific forms of cardiovascular diseases such as myocardial infarction, intracerebral and subarachnoid haemorrhage, or venous thrombosis.
The investigators will use linked electronic health records to investigate whether commonly diagnosed autoimmune disorders are associated with increased risk of CVD development and whether effects differ in men and women and change with age.
The linkage of Clinical Practice Research Datalink (CPRD) to the national registry of acute coronary syndromes (the Myocardial Ischaemia National Audit Project, MINAP), Hospital Episode Statistics (HES) and Office for National Statistics (ONS) available through CALIBER (Cardiovascular disease research using linked bespoke studies and electronic records), offers an opportunity to investigate the association between autoimmune disorders and the initial presentation of non-fatal and fatal specific cardiovascular phenotypes. The use of a systematic approach to investigate whether a range of commonly diagnosed autoimmune disorders are independent risk factors for several specific and well defined arterial and venous diseases will help to improve the investigators understanding of the role of autoimmune disorders in development of specific types of CVD in both men and women and in different age groups. It will also provide useful information to improve existing cardiovascular risk prediction methods that are used in clinical practice for patient management.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention | Other |
| Measure | Description | Time Frame |
|---|---|---|
| Rate ratios for the associations between presence of autoimmune disorders and initial presentation of myocardial infarction | Associated studies: overall, by sex, by age group | Followed for the duration of general practice registration between date of eligibility and date of administrative censoring, outcome occurrence or death (expected median of 5 years) |
| Rate ratios for the associations between presence of autoimmune disorders and initial presentation of stroke | Associated studies: overall, by sex, by age group | Followed for the duration of general practice registration between date of eligibility and date of administrative censoring, outcome occurrence or death (expected median of 5 years) |
| Rate ratios for the associations between presence of autoimmune disorders and initial presentation of stroke and venous thrombosis | Associated studies: overall, by sex, by age group | Followed for the duration of general practice registration between date of eligibility and date of administrative censoring, outcome occurrence or death (expected median of 5 years) |
| Measure | Description | Time Frame |
|---|---|---|
| Hazard ratios for the association between the presence of autoimmune disease and the initial presentation of stable angina | Associations studied: overall by sex by age group | Followed for the duration of general practice registration between date of eligibility and date of administrative censoring, outcome occurrence or death (expected median of 5 years) |
| Measure | Description | Time Frame |
|---|---|---|
| Cumulative incidence per autoimmune disease status | Associations studied: overall by sex by age group | Followed for the duration of general practice registration between date of eligibility and date of administrative censoring, outcome occurrence or death (expected median of 5 years) |
Inclusion Criteria:
Exclusion Criteria:
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Patients registered in Clinical Practice Research Datalink (CPRD) practices
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University College London | London | United Kingdom |
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| Hazard ratios for the association between the presence of autoimmune disease and the initial presentation of unstable angina | Associated studies: overall, by sex, by age group | Followed for the duration of general practice registration between date of eligibility and date of administrative censoring, outcome occurrence or death (expected median of 5 years) |
| Hazard ratios for the association between the presence of autoimmune disease and the initial presentation of heart failure | Associated studies: overall, by sex, by age group | Followed for the duration of general practice registration between date of eligibility and date of administrative censoring, outcome occurrence or death (expected median of 5 years) |
| Hazard ratios for the association between the presence of autoimmune disease and the initial presentation of peripheral arterial disease | Associated studies: overall, by sex, by age group | Followed for the duration of general practice registration between date of eligibility and date of administrative censoring, outcome occurrence or death (expected median of 5 years) |
| Hazard ratios for the association between the presence of autoimmune disease and the initial presentation of transient ischemic attack | Associated studies: overall, by sex, by age group | Followed for the duration of general practice registration between date of eligibility and date of administrative censoring, outcome occurrence or death (expected median of 5 years) |
| Hazard ratios for the association between the presence of autoimmune disease and the initial presentation of abdominal aortic aneurysm | Associated studies: overall, by sex, by age group | Followed for the duration of general practice registration between date of eligibility and date of administrative censoring, outcome occurrence or death (expected median of 5 years) |
| ID | Term |
|---|---|
| D009203 | Myocardial Infarction |
| D000083242 | Ischemic Stroke |
| D020521 | Stroke |
| D013345 | Subarachnoid Hemorrhage |
| D020246 | Venous Thrombosis |
| D002546 | Ischemic Attack, Transient |
| D060050 | Angina, Stable |
| D000789 | Angina, Unstable |
| D006333 | Heart Failure |
| D058729 | Peripheral Arterial Disease |
| D017544 | Aortic Aneurysm, Abdominal |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
| D007238 | Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D020300 | Intracranial Hemorrhages |
| D006470 | Hemorrhage |
| D013927 | Thrombosis |
| D016769 | Embolism and Thrombosis |
| D002545 | Brain Ischemia |
| D000787 | Angina Pectoris |
| D002637 | Chest Pain |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D050197 | Atherosclerosis |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D016491 | Peripheral Vascular Diseases |
| D001014 | Aortic Aneurysm |
| D000783 | Aneurysm |
| D001018 | Aortic Diseases |
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