Venipuncture and intravenous cannulation are the most common painful procedures, especially for the penitents who must receive large diameter venous catheter before surgery. In present study we would evaluate the safety and validity of lidocaine patches releasing such pain.

Inclusion Criteria:

• Patients who want to participate present study and sign the informed consent form
• Age from 18 to 65 years old
• Patients who need intravenous cannulation before surgery
• ASA class I-II and selected patients

Exclusion Criteria:

• Allergic to lidocaine or any other amide local anesthetics or any other medicine
• Allergic skin(allergic to past agent or other topical used medicine)
• Skin injured or inflection exist in the local site to patch
• Sensation disturbed in any limb
• Severe liver and kidney original disease:blood Aspertate aminotransferase and Alanine transaminase increased 1.5 times more than normal concentration; blood creatinine is higher than the normal range.
• Hemoglobin <80g/L
• ECG is significantly abnormal
• pregnant or possible pregnant or breastfeeding woman
• Patient who has consciousness disturbance can not make credible dialog with investigator.
• Those who are using other medicine may affect the evaluation of present patch
• Those who have participated in other clinical trail in the past three months
• Those excluded by investigator believed other reasons.