Effect of EGDT on Hepatic Perfusion in Patients With Septic Shock

Effect of EGDT on Hepatic Perfusion in Patients With Septic Shock

To observe the effect of early goal directed therapy (EGDT) on hepatic perfusion in patients with septic shock.

Hypothesis: Hepatic perfusion did not improved after EGDT in patients with septic shock.

Objective To observe the effect of early goal directed therapy (EGDT) on hepatic perfusion in patients with septic shock.

Methods A prospective observational study was carried out. The eligible patients were treated with the standard procedure of EGDT. The hemodynamic data were recorded. Oxygen metabolism and hepatic function were monitored. Indocyanine clearance test was applied to detect the hepatic perfusion. Hemodynamics, hepatic perfusion, oxygen metabolism and hepatic function were compared before treatment, after EGDT and 24 hours after EGDT.

Inclusion Criteria:

1. patients with septic shock
2. at least one of the EGDT criteria not achieved
3. informed consent accepted

Exclusion Criteria:

1. ages below 18 or above 90
2. pregnancy
3. the time elapsed over 24 hours after onset of septic shock
4. chronic liver disease
5. terminal stage of disease
6. brain death
7. other types of shock
8. brain injury
9. allergic to iodine or indocyanine