The purpose of this study is to evaluate the safety and tolerability of multiple ascending doses of HM10660A in subjects with chronic hepatitis C(HCV).

• To evaluate the repeat-dose pharmacokinetics (PK) of HM10660A when given by weekly, biweekly, and monthly subcutaneous (SC) injection.
• To evaluate the repeat-dose pharmacodynamics (PD) of HM10660A when given by weekly, biweekly, and monthly SC injection.
• To explore the antiviral activity of HM10660A at Week 4, Week 12, and Week 24.

Inclusion Criteria:

• Male or female, aged 18 to 65 years old, inclusive
• Willing and able to provide written informed consent.
• Previously untreated HCV infection with HCV RNA > 75,000 IU/mL at screening.
• HCV genotype 1a or 1b.
• Body mass index (BMI) between 18 and 38 kg/m2.
• Willing and able to comply with the protocol and available to complete the study schedule of assessments.

Exclusion Criteria:

• Pregnant women or women who may wish to become pregnant during the course of the study.
• Males and females of reproductive potential who are unwilling to use 2 forms of effective birth control throughout the duration of study treatment and for at least 6 months after the last dose of RBV. One method should include a condom with spermicide for males. Males must agree to refrain from sperm donation for at least 6 months after the last dose of RBV.
• Evidence of infection or co-infection with a non-genotype 1 HCV strain.
• Co-infection with hepatitis B virus (HBV) or human immunodeficiency virus (HIV).
• Lactating females