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Benign adenomas of the colon have the potential to degenerate and become malignant. Therefore adenomatous polyps should be detected and resected during colonoscopy. Factors like advanced age and male gender are associated with the detection of adenomas. The same epidemiological pattern can be found with regard to colon diverticula. Furthermore, western world countries report higher incidences of both colorectal carcinoma as well as diverticular disease. It is not known whether a correlation exists between both entities. Some recent data have postulated higher adenoma detection rates in patients with concomitant diverticular disease (Rondagh EJ et al. Eur J Gastroenterol Hepatol. 2011; 23:1050-5. Kieff BJ et al. Am J Gastroenterol 2004; 99: 2007-11). If a positive correlation could be found this would possibly affect recommendations regarding colonoscopy surveillance intervals for patients with and without diverticular disease. The investigators therefore plan to conduct the following trial.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Routine colonoscopy | Patients receiving routine colonoscopy (for a multitude of indications) at the study centers are eligible for participation |
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| Measure | Description | Time Frame |
|---|---|---|
| Adenoma detection rate | After obtaining the histopathological diagnosis of resected polyps (approximately 3 days - 2 weeks after colonoscopy ) accuracy of optical diagnosis can be determined | up to 2 weeks (participants will be followed for the duration of hospital stay or outpatient treatment, an expected average of 2 weeks) |
| Measure | Description | Time Frame |
|---|---|---|
| Polyp detection rate | a maximum of one day is expected for colonoscopy | up to one day |
| Frequency of colon diverticulosis | a maximum of one day is expected for colonoscopy |
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Inclusion Criteria:
Exclusion Criteria:
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Patients receiving routine colonoscopy at the both study centers are eligible for participation.
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| Name | Affiliation | Role |
|---|---|---|
| Peter Klare, MD | II. Medizinische Klinik, Klinikum rechts der Isar der Technischen Universität München, Germany | Principal Investigator |
| Peter Born, Prof. Dr. | Innere Medizin II, Rotkreuzklinikum München, Nymphenburger Str. 163, München, Germany | Study Chair |
| Stefan von Delius, MD | II. Medizinische Klinik, Klinikum rechts der Isar der Technischen Universität München, Germany | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rotkreuzklinikum München | München | Deutschland | 80634 | Germany | ||
| II Medizinische Klinik am Klinikum rechts der Isar der Technischen Universität München |
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| ID | Term |
|---|---|
| D004240 | Diverticulum |
| D000236 | Adenoma |
| D000076385 | Diverticular Diseases |
| D015179 | Colorectal Neoplasms |
| D011127 | Polyps |
| ID | Term |
|---|---|
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
| D020763 | Pathological Conditions, Anatomical |
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Colon polyps and mucosa
| up to one day |
| München |
| Deutschland |
| 81677 |
| Germany |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |