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Anterior scalp block with 0.5% plain Marcaine 20 ml. may reduce the intraoperative opioid consumption in neurosurgical patients who undergoing the supratentorial craniotomy compared to those who receive 0.9% normal saline solution (placebo).
Anterior scalp block with 0.5% plain Marcaine 20 ml. may reduce the intraoperative opioid consumption in neurosurgical patients who undergoing the supratentorial craniotomy compared to those who receive 0.9% normal saline solution (placebo).
A Prospective Randomized Double Blind Control
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Scalp block with 0.5% plain marcaine | Experimental | Anterior scalp block with 0.5% plain Marcaine 20 ml. |
|
| Scalp block with 0.9% normal saline | Placebo Comparator | Anterior scalp block with 0.9% normal saline 20 ml. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Scalp block with 0.5% plain Marcaine | Drug | Anterior scalp block will be done by using 0.5% plain Marcaine 20 ml. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Intraoperative opioid consumption | The overall intravenous fentanyl consumption (microgram/ kilogram) during the surgery. The decision to administer fentanyl is guided by the changes of blood pressure and/ or heart rate greater than 20% from baseline level. | During the supratentorial craniotomy surgery |
| Measure | Description | Time Frame |
|---|---|---|
| systolic blood pressure change | The maximal systolic blood pressure within the first 5 minutes after skull pin insertion will be recorded. The systolic blood pressure change from baseline will be calculated. The unit is mmHg. | within 5 minutes after skull pin insertion |
| Heart rate change |
| Measure | Description | Time Frame |
|---|---|---|
| extubation | The rate of immediate extubation before transferring to the intensive care unit (ICU) compared between patients who received 0.5% plain Marcaine and 0.9% normal saline solution. | end of surgery, before transferring to the intensive care unit |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Pathomporn Pin-on, M.D. | Chiang Mai University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chiang Mai University | Chiang Mai | Chiang Mai | 50200 | Thailand |
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| ID | Term |
|---|---|
| D001932 | Brain Neoplasms |
| ID | Term |
|---|---|
| D016543 | Central Nervous System Neoplasms |
| D009423 | Nervous System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| D000077330 | Saline Solution |
| C066096 | PAVE protocol 2 |
| ID | Term |
|---|---|
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |
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| Scalp block with 0.9% normal saline | Drug | Anterior scalp block will be done by using 0.9% normal saline 20 ml. |
|
|
The maximal heart rate within the first 5 minutes after skull pin insertion will be recorded. The heart rate change from baseline level will be calculated. The unit is beats per minute. |
| within 5 minutes after skull pin insertion |
| D001927 |
| Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |