Comparison Between Budesonide and Dexamethasone Treatments for Respiratory Discomfort After Extubation on Children

Comparison Between Inhaled Budesonide and Intravenous Dexamethasone Treatments for Postextubation Stridor in Children

The study aims to analyze and compare the clinical effects of using inhaled budesonide or intravenous dexamethasone in the treatment of postextubation stridor on children admitted to the pediatric intensive care units at Hospital Municipal do M´Boi Mirim and Hospital Albert Einstein.

The investigators propose to perform a prospective, randomized, controlled and double-blind non inferiority study enrolling 70 children with postextubation stridor. The population will be divided in two groups: group 1 will receive inhaled budesonide and IV NS (intravenous normal saline) and group 2 will receive IV (intravenous) dexamethasone and inhaled normal saline. The study aims to analyze and compare (I would just say compare) the clinical effects of using inhaled budesonide or IV dexamethasone in the treatment of postextubation stridor on children admitted to the pediatric intensive care units at Hospital Municipal do M´Boi Mirim and Hospital Albert Einstein.

Inclusion Criteria:

• patients intubated for periods longer than 24hs
• age between 28 days and than 15 years
• post extubation stridor must be clinically diagnosticated by a MD
• informed consent must be obtained

Exclusion Criteria:

• patients under palliative care
• presence of neuromuscular disease
• previous airway pathologies
• epiglottitis, aspiration of foreign bodies
• viral laryngitis
• former airway surgery
• patients previously included in the study within the same hospital admission
• corticosteroid use in the 48hs preceding extubation