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| Name | Class |
|---|---|
| Medical Research Council Cognition and Brain Sciences Unit | OTHER_GOV |
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The purpose of this study is to evaluate the feasibility of administering a 20-day preoperative cognitive training intervention (Cog-Train) to a widely inclusive sample of cardiac surgical patients.
Cognitive outcomes remain poor after cardiac surgery. Data from the field of cognitive neuroscience suggests that cognitive training, which harnesses the brain's adaptive plasticity to improve, maintain, or restore function in a target area, can be used to strengthen brain resilience and improve cognitive outcomes following challenge. While its effectiveness has been demonstrated in older adults as well as in other (nonsurgical) patient populations, no training intervention like this has ever before been used in any surgical patient in the preoperative period. The purpose of this study is to evaluate the feasibility of administering a 20-day cognitive training intervention (Cog-Train) to a widely inclusive sample of cardiac surgical patients before their surgery. Data obtained will be used to design a full-scale randomised controlled trial (RCT) on Cog-Train's effectiveness in improving postoperative cognitive outcomes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cog-Train Intervention | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cog-Train Intervention | Behavioral | Twenty-one days prior to surgery, patients will begin self-administering the intervention using an iPad tablet. This intervention will consist with daily sessions of at least 20 minutes of the Cog-Train task (the task and regimen used to obtain robust effects in previous studies by members of our group). Cog-Train is an n-back task - an adaptive working memory computer game that extends players' working memory capacity by getting progressively more difficult as the player's performance increases. |
| Measure | Description | Time Frame |
|---|---|---|
| Training performance gain | Average increase in training task level achieved from first to last training day | From 21 days prior to scheduled surgery to 1 day prior to scheduled surgery |
| Adherence to training regimen | Mean number of training days completed according to instructions | From 21 days prior to scheduled surgery to 1 day prior to scheduled surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Recruitment and retention | Proportion of patients approached who can do the task and are willing to take part | 10 weeks |
| Satisfaction and acceptability | Self report questionnaire |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Kimberly Giraud, PhD | Contact | 01480 830541 | kimberly.giraud@papworth.nhs.uk |
| Name | Affiliation | Role |
|---|---|---|
| Alain Vuylsteke, MD | Papworth Hospital NHS Foundation Trust | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Papworth Hospital NHS Foundation Trust | Cambridge | Cambridgeshire | CB23 3RE | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21949712 | Background | Schweizer S, Hampshire A, Dalgleish T. Extending brain-training to the affective domain: increasing cognitive and affective executive control through emotional working memory training. PLoS One. 2011;6(9):e24372. doi: 10.1371/journal.pone.0024372. Epub 2011 Sep 19. |
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| ID | Term |
|---|---|
| D000079690 | Postoperative Cognitive Complications |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D060825 | Cognitive Dysfunction |
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| At 1 day prior to scheduled surgery |
| Side-effects | Side effects and severity reported by patients and proportion of patients who reported side-effects | From 21 days prior to scheduled surgery to up to 14 days after surgery |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |