The purpose of this study is to demonstrate improved pain control and outcomes in wrist operations with the use of a long-acting local anesthetic, EXPAREL, when compared to the use of the standard local anesthetic, Marcaine.

Inclusion Criteria:

• Age > 18 years
• ASA physical status 1-3
• Undergoing either carpometacarpal arthroplasty or proximal row carpectomy operation
• Physically and mentally able to participate in the study and complete all study assessments
• Able to voluntarily give fully informed consent to participate in this study and complete all study assessments within the timeframes required.

Exclusion Criteria:

• History of hypersensitivity or idiosyncratic reactions to amide-type local anesthetics
• Any patient whose anatomy, or surgical procedure, in the opinion of the Investigator, might preclude the potential successful local administration of EXPAREL
• Patients who have received any investigational drug within 30 days prior to EXPAREL administration, or planned administration of another investigational product or procedure during their participation in this study
• Any chronic condition requiring use of opioids for treatment of the medical condition for three (3) months or more
• Confirmed pregnancy at time of enrollment
• Patients unable to comply with the study requirements, i.e. inaccessible by phone, or deaf