The purpose of the study is to show that 3 targeted biopsies on the suspicious image detected by IRM, guided by a fusion of MRI and ultrasound- images with the Koelis ® system, will get no lower rate of cancer detection than those obtained by 12 systematic transrectal ultrasound-guided biopsies of the prostate.

The act of current practice evaluated by this research is the act of prostate biopsies : the patient will have to undergo 12 systematized transrectal echography guided biopsies of the prostate and 3 additional biopsies targeted on the suspicious lesion detected with MRI, which are both done in current practice.

• A first operator is not informed of the location of the target. He will perform a series of 12 systematic transrectal ultrasound-guided biopsies of the prostate.
• Immediately after the second operator will perform 3 additional targeted biopsies on the suspicious image detected by IRM, guided by a fusion of MRI and ultrasound- images with the Koelis ® system

Act added by the research: Using a fusion of MRI - ultrasound images software system (Koelis ®).

Inclusion Criteria:

• patient from 45 to 75 years old;
• Serum level of PSA > 4,0 ng / mL;
• Multiparametric prostate IRM, performed before inclusion and which confirm the diagnosis of suspected target;
• No opposition of the patient notified in the medical record
• patient member in a national insurance scheme.

Exclusion Criteria:

• Previous prostate biopsy;
• suspicious digital rectal examination;
• serum PSA > 20,0 ng / mL;
• treatment with 5 alpha reductase inhibitor during the last 3 months;
• untreated urinary infection