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The objective of this study was to objectively measure daily physical activity and spatiotemporal gait pattern, as well as improvements in self reported symptoms and quality of life, before and six weeks after an intra-articular corticosteroids injection in patients suffering from knee osteoarthritis. Fourteen patients with unilateral knee osteoarthritis were recruited. The intra-articular corticosteroid injection was given at the end of the second week. Physical activity was objectively measured by an accelerometer worn by the participants for eight weeks. In addition, the Western Ontario and McMaster Universities Arthritis Index (WOMAC), the Medical Outcome Study Short Form-36 (MOS-SF36) and gait trials were completed every two weeks to assess symptoms, quality of life and spatiotemporal parameters of gait.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Injection | Experimental | Corticosteroids injection |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Corticosteroids injection | Drug | A solution of triamcinolone 40 mg (Kenalog) mixed with 3 cc of 2% xylocaine without epinephrine. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in Knee pain | Change from Baseline at 2, 4 and 6 weeks | |
| Change in physical activity | Change from baseline at 2, 4 and 6 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change in function and quality of life | Assessment with WOMAC and MOS-SF36 questionnaires | Change from baseline at 2, 4 and 6 weeks |
| Change in Spatiotemporal gait parameters | Gait symmetry was verified with regards to the swing and stance phase durations and step length |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Philippe Corbeil, PhD | Laval University | Study Director |
| Yoann Dessery, MSc | Laval University | Principal Investigator |
| Étienne Belzile, MD | Laval University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pavillon de l'Éducation Physique et des Sports - Université Laval | Québec | Quebec | G1V 0A6 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25478585 | Derived | Dessery Y, Belzile EL, Turmel S, Dore J, Diallo B, Corbeil P. Modulation of physical activity to optimize pain sensation following an intra-articular corticosteroid injection in patients with knee osteoarthritis. ScientificWorldJournal. 2014;2014:209165. doi: 10.1155/2014/209165. Epub 2014 Nov 16. |
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| ID | Term |
|---|---|
| D020370 | Osteoarthritis, Knee |
| ID | Term |
|---|---|
| D010003 | Osteoarthritis |
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
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| ID | Term |
|---|---|
| D000305 | Adrenal Cortex Hormones |
| ID | Term |
|---|---|
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
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| Change from Baseline at 2, 4 and 6 weeks |
| D012216 |
| Rheumatic Diseases |