The effect of Pulmonary Rehabilitation in patients with bronchiectasis (BC) is not sufficiently studied. The aim of this study is to assess the clinical and biological response of a Pulmonary Rehabilitation Program (PRP) for 12 weeks in BC vs PRP plus hyperproteic oral nutritional supplement enriched with beta-hydroxy-beta-methylbutyrate (HMB).

Methods: single center randomized controlled trial, parallel treatment design: Participants will be randomized assigned either will receive (n=14) PRP for 60 minutes, two supervised sessions per week in the hospital and one unsupervised session at home vs PRP (n=14) plus ONS (one can per day).

Outcome assessments will be performed at baseline, 12 weeks and 24 weeks:

1.- effort capacity –cardiopulmonary exercise test-, 2.- body composition (anthropometry, lean body mass by dual energy X-ray absorptiometry and bioimpedance, phase angle), 3.- peripheral muscle strength (dynamometry and respiratory -PEM (maximum expiratory pressure)and PIM (minimum expiratory pressure)-), 4.- spirometry, 5.- respiratory symptoms (bronchorrhea, dyspnoea, exacerbations),6.- level of physical activity (IPAQ questionnaire plus objective physical activity (WGT3X)), 7.- quality of life (QOL-B-Spain) , 8.-psychological symptoms (HASD) and 9.- biological markers of inflammation (leptin, adiponectin, interleukin-6, tumor necrosis factor-alpha, ultrasensitive C-reactive protein, GPR55 (G protein-coupled receptor 55) RNAm (messenger ribonucleic acid) expression in white blood cells) and oxidation (total antioxidant capacity, superoxide dismutase activity, 8-iso-prostaglandin F2a, Thiobarbituric acid reactive substances).

Inclusion Criteria:

• Patients ages from 18-80 (both included)
• Patients with bronchiectasis, not cystic fibrosis bronchiectasis.
• Bronchiectasis diagnosed by high resolution computed tomography (HRCT). of the chest
• Patients followed in Bronchiectasis and Cystic Fibrosis Units in the Hospital.
• BMI > 18.5 in patients under 65 years old, and > 20kg/m2 in patients over this age.
• Ambulatory patients.

Exclusion Criteria:

• Use of oral corticoids.
• Respiratory exacerbation. If a patient had a respiratory exacerbation or a recent hospital admission, their participation will be postponed for at least 60 days til any acute disease is resolved.
• Prior oral or parenteral supplements intake.
• Traumatological, neurological or cardiovascular diseases that prevent patients from performing the training.
• Life threatening hemoptysis in the past year.
• Patients with cancer, major surgery in the previous three months, participating in another study, patients who are pregnant or may become pregnant, patients with acute intestinal disease, acute heart failure, severe hepatic failure or dialysis.
• Gastrectomy, gastroparesis or other alterations of gastric emptying.
• Enteral tube feeding, galactosemia, Fructosemia.
• Allergy or known sensitivity to any ingredient of the enteral formula.
• Cystic fibrosis.
• Included in active list for transplantation.
• Drug or alcohol abuse.
• No informed consent signed.