Impact of Bismuth Subsalicylate on Antimicrobial Use Among Adult Diarrhea Outpatients--Pakistan

Randomized, Double-blind, Placebo-controlled Trial of the Impact of Bismuth Subsalicylate on Antimicrobial Use Among Adult Diarrhea Outpatients in Pakistan

The purpose of this study is to learn whether bismuth subsalicylate can reduce use of antibiotics among adults with diarrhea in Pakistan.

Inclusion Criteria:

• Persons aged 15 - 65 years old
• Presenting with mild to moderate, non-bloody, acute diarrhea (≥3 loose stools/day for <3 days) to participating health care settings
• For whom the study physicians recommend antimicrobial treatment

Exclusion Criteria:

• Is pregnant
• Requires hospitalization
• Has signs or symptoms of septicemia
• Has a primary complaint of another acute illness
• Has a serious chronic illness
• Has an allergy to aspirin
• Has been exposed to antimicrobial or antidiarrheal medications within 72 hours of enrollment
• Previously enrolled in study