Peanut Oral Induction Tolerance in Peanut's Allergic Teenagers

Peanut Oral Induction Tolerance in Peanut's Allergic Teenagers

The primary purpose of the protocol is to evaluate the efficacy of a protocol for induction of tolerance to peanut ingestion increasing doses. The secondary purpose is to determine the interest of a prolonged maintenance therapy

Prospective randomized double blind, placebo controlled, protocol in two phases: 1/ active treatment versus placebo for induction phase; 2/ long versus short maintenance

Inclusion Criteria:

• Adolescents between 12 and 18 years
• Clinical History of allergic manifestation within one hour of ingestion of peanuts or Double-Blind, Placebo-Controlled Food Challenges (DBPCFCs) peanut positive below the threshold of 2 grams
• Bad reaction peanut demonstrated by positive Patch Test (PT ≥ 3 mm above the negative control) and specific IgE f13> 12 IU / mL and / or rAra h2> 5.8 IU / mL
• Previous follow at least 1 year

Exclusion Criteria:

• Lack of response during the initial DBPCFCs to the cumulative dose of 2 grams of peanut or instant dose of 1 gram of peanut

• Uncontrolled asthma and / or severe over the previous year

• Atopic dermatitis uncontrolled

• Initial severe anaphylaxis requiring hospitalization in intensive care

• Presence of a major allergy with anaphylaxis at another allergen risk (milk, egg, nuts, or other)

• Home away from a center could support a severe reaction in emergency

• Lack of motivation and understanding of parents and / or child

• Incapacity

  • to establish a daily logbook of clinical monitoring
  • to support severe reaction after eating peanut
  • to follow a regular peanut ingestion protocol