Low intensity shockwaves have been proven in animal and human studies to increase tissue perfusion, promote angiogenesis and tissue regeneration and improve neural function.

The hypothesis of this study is that shockwave therapy could improve the symptoms of patients with resistant hypertension.

Inclusion Criteria:

• Subjects who have provided written informed consent.
• Age ≥18 and ≤80 years old.
• Office systolic blood pressure that remains ≥160 mmHg (≥150 mmHg for patient with type 2 diabetes) despite the stable use of ≥3 antihypertensive medications concurrently at maximally tolerated doses, of which one is a diuretic (unless there is a tolerance or a contraindication for a diuretics).
• Able and willing to comply with the required follow-up schedule.

Exclusion Criteria:

• Subjects who have participated in a clinical study involving another investigational drug or device within 4 weeks prior to Screening.
• Have hypertension secondary to an identifiable and treatable cause or take medication that can raise the BP.
• Prior renal artery intervention (balloon angioplasty or stenting).
• Pregnancy.
• Uncompensated heart failure.
• Chronic Liver Disease.
• Patients with skin wound / infection at the treatment area.
• Subjects who take oral anti-coagulants.
• Local tumor of treatment area.