The primary end point is revascularization based on modified Thrombolysis in Cerebral Infarction score (mTICI). Per protocol, successful revascularization is defined as having a modified TICI score ≥2b at the end of the procedure.

Modified TICI Scale (mTICI Scale) Grade 0 - No Perfusion Grade 1 - Penetration with Minimal Perfusion Grade 2 - Partial Perfusion Grade 2a - Only partial filling (< 50%) of the entire vascular territory is visualized.

Grade 2b - Filling of > 50% all of the expected vascular territory is visualized, but the filling is slower than normal.

Grade 3 - Complete Perfusion

Intention to Treat (ITT)

The Modified Rankin Scale mRS is a scale for measuring the degree of disability or dependence in the daily activities of people who have suffered a stroke or other causes of neurological disability.

A good clinical outcome = mRS scale 0-2. 0 - No symptoms at all.

1. - No significant disability despite symptoms; able to carry out all usual duties and activities.
2. - Slight disability; unable to carry out all previous activities, but able to look after own affairs without assistance.
3. - Moderate disability; requiring some help, but able to walk without assistance.
4. - Moderately severe disability; unable to walk without assistance and unable to attend to own bodily needs without assistance.
5. - Severe disability; bedridden, incontinent and requiring constant nursing care and attention.
6. - Dead.

Per Protocol. This endpoint includes patient with a baseline and 90 day assessment. 1997 participants that underwent mechanical thrombectomy with the Trevo retriever completed both assessments.

Overall mortality rate

Intention to Treat (ITT)

Rate of Device and Procedure related serious adverse events (SAE)

Intention to Treat (ITT)

Neurological Deterioration at 24 hours post procedure, defined as a 4 point or more increase in the NIHSS score over the baseline score.

Intention to Treat