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When becoming a parent of a preterm infant there is an increased risk of stress. There are a number of studies showing that parental stress has a negative impact on their engagement with their child. Other studies, on the other hand, show that different intervention programs with the aim to strengthen the relationship can decrease parental stress and hence affect the parent-infant interaction in a positive way. Structured intervention programs for preterm infants have also been successful in improving the infants' cognitive functions.
The investigators have developed a program with the aim to strengthen the parent-infant interaction for late preterm infants. The observational program is called LiMoNid. Our hypothesis is that LiMoNid will strengthen the parents' own parental abilities and give them a deeper understanding of their child. They will hopefully develop more skills on how to communicate with their child; to see, interpret, understand and approach the child, which can lead to an improved parent-child interaction. Parental stress may also be reduced by increased understanding and control. Regarding the child itself, we hypothesize that the psychological development will be affected depending on the communication with the caregiver and depending on the support it has received in expressing its feelings and needs. The emotional regulation should be strengthened by such an intervention.
The aim is to study if LiMoNid can have an impact on cognition, stress, parent-child interaction.
The Design is a randomised controlled study in two groups; intervention group versus standard care. Parents who meet the inclusion criteria are given oral and written information about the study aim and procedure and are asked for participation. If the parents consent they will be randomised to one of two groups. Follow-ups will be conducted at 1 month, 4 months, 10-12 months corrected age and when the child is 4 years.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Standard care | No Intervention | The family receive standard care when enrolled in the Neonatal intensive care unit | |
| Observation | Experimental | The family receive standard care when enrolled in the Neonatal intensive care unit and are also included in an observational program called LiMoNid. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| LiMoNid | Behavioral | One LiMoNid observation will be performed on day 1-3 post birth, one in time of discharge, and one in the home when the infant has reached 40 weeks (+/- 2 week). All observations are performed in presence of and in collaboration with the parents with the outspoken aim to guide the parents to learn how to read and respond to their infant' signals |
| Measure | Description | Time Frame |
|---|---|---|
| Cognitive abilities | Bayley Scales of Infant Development | 11 months |
| Measure | Description | Time Frame |
|---|---|---|
| Stress reactivity | Salivary cortisol reactivity in relation to bath | 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| Parent-child interaction | Ainsworth sensitivity scale | 1 month |
| Stress reactivity | Salivary cortisol reactivity in relation to still-face | 4 months |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Evalotte Morelius, PhD | Linkoeping University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Linkoping University Hospital | Linköping | 581 85 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35702001 | Result | Helmer CS, Thornberg UB, Abrahamsson T, Morelius E. Mothers' experiences of a new early collaborative intervention, the EACI, in the neonatal period: A qualitative study. J Clin Nurs. 2023 Jun;32(11-12):2892-2902. doi: 10.1111/jocn.16412. Epub 2022 Jun 14. | |
| 34205660 | Result | Helmer CS, Thornberg UB, Morelius E. An Early Collaborative Intervention Focusing on Parent-Infant Interaction in the Neonatal Period. A Descriptive Study of the Developmental Framework. Int J Environ Res Public Health. 2021 Jun 21;18(12):6656. doi: 10.3390/ijerph18126656. |
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| ID | Term |
|---|---|
| D047928 | Premature Birth |
| D013315 | Stress, Psychological |
| ID | Term |
|---|---|
| D007752 | Obstetric Labor, Premature |
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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|
| Parent-child interaction | Still-face and Ainsworth sensitivity scale | 4 months |
| Parental stress | Edinburgh Post Depression Scale (EPDS) and State-Trait and Anxiety Inventory, short version (STAI) | 1 month |
| Parental stress | Edinburgh Post Depression Scale (EPDS), State-Trait and Anxiety Inventory, short version (STAI) and Swedish Parenthood Stress Questionnaire (SPSQ) | 4 months |
| Parent-child interaction | Infant Parent Social Interaction (IPSIC) and Attachment Story Stems | 11 months |
| Stress reactivity | Salivary cortisol reactivity in relation to a standardized play-situation, Infant Parent Social Interaction (IPSIC) | 11 months |
| Parental stress | State-Trait and Anxiety Inventory, short version (STAI) and Swedish Parenthood Stress Questionnaire (SPSQ) | 11 months |
| Emotions | Ages and Stages Questionnaire: Social and emotional (ASQ-SE) | 11 months |
| Cognitive abilities | Wechsler Preschool and Primary Scale of Intelligence (WPPSI-III) | 4 years |
| Parental stress | State-Trait and Anxiety Inventory, short version (STAI) | 4 years |
| Parental style | Parenting Scale (PS) | 4 years |
| Emotions | Ages and Stages Questionnaire: Social and emotional (ASQ-SE) | 4 months |
| Emotions | Ages and Stages Questionnaire: Social and emotional (ASQ-SE) and Emotion Regulation Questionnaire for Children | 4 years |
| 41782918 | Derived | Helmer CS, Thornberg UB, Abrahamsson T, Morelius E. Impacts of the Early Collaborative Intervention on mother-preterm infant interaction at one month of age: Secondary analysis of a randomized controlled trial. Int J Nurs Stud Adv. 2026 Feb 9;10:100507. doi: 10.1016/j.ijnsa.2026.100507. eCollection 2026 Jun. |
| 40511708 | Derived | Birberg Thornberg U, Koch FS, Helmer CS, Tell J, Nyberg E, Abrahamsson T, Morelius E. Moderate-To-Late Preterm Infants Benefit From the Early Collaborative Intervention: Primary Outcomes of an RCT. Acta Paediatr. 2025 Nov;114(11):2838-2846. doi: 10.1111/apa.70173. Epub 2025 Jun 13. |
| D000091642 | Urogenital Diseases |
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |