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| ID | Type | Description | Link |
|---|---|---|---|
| BD2013-104 | Other Identifier | Cha medical university IRB |
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| Name | Class |
|---|---|
| The Korean Society of Ginseng | OTHER |
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Aim : Investigated the effects of Korean red ginseng supplementation on metabolic parameters such as cholesterol, blood pressure and glucose.
Randomized Control Trial.
Methods : A randomized, double-blind, placebo-controlled, single-center study in 60 subjects who are not taking drugs that could affect metabolic and vascular function. Subjects will be randomized into a Korean red ginseng (3.0g/d) group or placebo group for a 4-week study.
We will collect anthropometric measurements, blood for laboratory testing, inflammatory marker, hormones and mitochondrial DNA copy number.
Subject : Older than 40 years of age, presented with metabolic syndrome. Subjects were excluded if they were taking drugs that could affect metabolic and vascular function, including BP control drug, anti-diabetic drugs and lipid-lowering drugs.
Measurement : We will collect anthropometric measurements and blood for laboratory testing at the initial(week 0) and final (week 4)visits. Serum levels of blood glucose, insulin, total cholesterol, HDL-cholesterol,triglyceride, and DNA copy number of mitochondria.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ginsenoside | Experimental | Ginsenoside : Intervention : ginsenoside, 3 gram / day, for 28 days in intervention group |
|
| Dietary fiber fill | Placebo Comparator | Dietary fiber fill manufactured to mimic Ginsenoside tablet |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ginsenoside | Dietary Supplement | 3.0 g/ d for 28 days |
|
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| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in metabolic syndrome profile at week 4 | Total cholesterol, HDL-Cholesterol, Glucose, Blood Pressure, Body weight | Baseline and 4 weeks from intake of Ginsenoside |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in hormones at week 4. | insulin ,cortisol, testosterone, somatomedin-c and DHEAS | Initial and 4 weeks later |
| Measure | Description | Time Frame |
|---|---|---|
| Mitochondria DNA copy number | initial and 4 weeks later |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| DH Jung, MPH | Contact | +82) 10-4204-8998 | balsan2@empas.com | |
| YJ Lee, Ph.D | Contact | +82) 3015-2011 | ykyjhome@yuhs.ac |
| Name | Affiliation | Role |
|---|---|---|
| DH Jung, MPH.M.D. | Cha Medical University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bundang CHA Hospital | Seoul | Kyeonggi-do | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22916320 | Background | Park BJ, Lee YJ, Lee HR, Jung DH, Na HY, Kim HB, Shim JY. Effects of Korean Red Ginseng on Cardiovascular Risks in Subjects with Metabolic Syndrome: a Double-blind Randomized Controlled Study. Korean J Fam Med. 2012 Jul;33(4):190-6. doi: 10.4082/kjfm.2012.33.4.190. Epub 2012 Jul 25. | |
| 18339495 | Background | Rasheed N, Tyagi E, Ahmad A, Siripurapu KB, Lahiri S, Shukla R, Palit G. Involvement of monoamines and proinflammatory cytokines in mediating the anti-stress effects of Panax quinquefolium. J Ethnopharmacol. 2008 May 8;117(2):257-62. doi: 10.1016/j.jep.2008.01.035. Epub 2008 Feb 8. |
| Label | URL |
|---|---|
| The goal of Korean ginsengsociety is to help elevate the level of ginseng science in both theory and practice by providing technical information to the ginseng industry, providing ginseng-related education to the community. | View source |
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| ID | Term |
|---|---|
| D024821 | Metabolic Syndrome |
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
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| ID | Term |
|---|---|
| D036145 | Ginsenosides |
| ID | Term |
|---|---|
| D014315 | Triterpenes |
| D013729 | Terpenes |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
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| Dietary fiber fill | Dietary Supplement | 3g/day, 28days |
|
| 23089630 | Background | Lamers F, Vogelzangs N, Merikangas KR, de Jonge P, Beekman AT, Penninx BW. Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression. Mol Psychiatry. 2013 Jun;18(6):692-9. doi: 10.1038/mp.2012.144. Epub 2012 Oct 23. |
| 17615678 | Background | Yun SN, Ko SK, Lee KH, Chung SH. Vinegar-processed ginseng radix improves metabolic syndrome induced by a high fat diet in ICR mice. Arch Pharm Res. 2007 May;30(5):587-95. doi: 10.1007/BF02977653. |
| 22589267 | Background | Kim JH, Lee DC. Mitochondrial DNA copy number in peripheral blood is associated with femoral neck bone mineral density in postmenopausal women. J Rheumatol. 2012 Jul;39(7):1465-72. doi: 10.3899/jrheum.111444. Epub 2012 May 15. |
| 26860800 | Derived | Jung DH, Lee YJ, Kim CB, Kim JY, Shin SH, Park JK. Effects of ginseng on peripheral blood mitochondrial DNA copy number and hormones in men with metabolic syndrome: A randomized clinical and pilot study. Complement Ther Med. 2016 Feb;24:40-6. doi: 10.1016/j.ctim.2015.12.001. Epub 2015 Dec 4. |
| D009750 |
| Nutritional and Metabolic Diseases |
| D012503 |
| Saponins |
| D006027 | Glycosides |
| D002241 | Carbohydrates |