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Induced hypovolemia is known to improve surgical field during living donor hepatectomy. This procedure is conventionally guided by monitoring the central venous pressure (CVP). Stroke volume variation (SVV) is a novel method to substitute with CVP to monitor cardiac preload. The investigators try to evaluate the relationship between CVP and SVV during CVP-guided vasodilator induced hypovolemia (validation study). Then, feasibility of vasodilator induced hypovolemia using the SVV calculated from the validation study will be tested (feasibility study).
This is a 2-phases study.
first phase validation study : Evaluation of the relationship between CVP and SVV during CVP-guided vasodilator induced hypovolemia
second phase feasibility study
: Comparison of the surgical field grade between validation study group(CVP guided group) and feasibility study group(SVV guided group)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CVP | Active Comparator | Central venous pressure-guided vasodilator-induced hypovolemia |
|
| SVV | Experimental | stroke volume variation-guided vasodilator-induced hypovolemia |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| vasodilator induced hypovolemia | Procedure |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| target value of SVV | Target value of SVV is calculated from the linear regression equation that was calculated from scatter plot made with CVP and SVV values during CVP-guided vasodilator induced hypovolemia (validation study). | during living donor hepatectomy |
| Measure | Description | Time Frame |
|---|---|---|
| surgical field | <4 point scale> Grade l: Very lax IVC and hepatic veins, minimal bleeding at resection plane, very easy to operate Grade ll: Lax IVC and hepatic veins, a little bleeding at resection plane, easy to operate Grade lll: Tense IVC and hepatic veins, appreciable bleeding at resection plane, somewhat difficult to operate Grade lV: Very tense IVC and hepatic veins, profuse bleeding at resection plane, very difficult to operate |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul national University Hospital | Seoul | 110-744 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28632543 | Derived | Lee J, Kim WH, Ryu HG, Lee HC, Chung EJ, Yang SM, Jung CW. Stroke Volume Variation-Guided Versus Central Venous Pressure-Guided Low Central Venous Pressure With Milrinone During Living Donor Hepatectomy: A Randomized Double-Blinded Clinical Trial. Anesth Analg. 2017 Aug;125(2):423-430. doi: 10.1213/ANE.0000000000002197. |
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| ID | Term |
|---|---|
| D006470 | Hemorrhage |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| during living donor hepatectomy |
| use of inotropics | during living donor hepatectomy |
| estimated blood loss | during living donor hepatectomy |