Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This study is a randomized, double blind, controlled clinical trials assess the efficacy of the ginger oral treatment on sperm DNA fragmentation, sperm parameters and male hormones.
Sperm DNA fragmentation is known to affect male fertility. Previous findings have suggested the implication of oxidative stress in the etiology of this pathological condition. The present study was designed to find out DNA fragmentation in ejaculated spermatozoa can be reduced by oral treatment with Ginger extract. 71 men with unexplained or Idiopathic infertility were randomized between a Ginger treatment (500 milligram daily for 3months) group and a placebo group.
Sperm DNA fragmentation was evaluated by Terminal deoxyribonucleotidyltransferase-mediated dUTP nick-end labeling assay (TUNEL) before and after treatment. No differences in basic sperm parameters were found between the Ginger treatment and the placebo group before or after treatment. However, the percentage of DNA-fragmented spermatozoa was markedly reduced (P< .005) in the Ginger treatment group after the treatment as compared with the pretreatment values). No difference in the pretreatment and post treatment incidence of sperm DNA fragmentation was observed in the placebo group. These data show that sperm DNA damage can be efficiently treated with oral Ginger extract administered during a relatively short time period.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ginger | Experimental | The patients with infertility that underwent oral administration of ginger. |
|
| Placebo | Placebo Comparator | The patients with infertility that receive placebo. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| oral administration of ginger | Drug | Oral administration of ginger in patients with infertility. |
|
| Measure | Description | Time Frame |
|---|---|---|
| sperm DNA fragmentation | Evaluation the percent of the reduction of sperm DNA fragmentation 3 months after ginger administration. | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| male hormones | Evaluation the effect of ginger on male hormones 3 months after oral administration. | 3months |
| sperm count | Evaluation the ginger on sperm count 3 months after oral administration. |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Hamid Gourabi, PhD | Head of Royan Institute | Study Chair |
| Ali DaliriHampa, MD | Department of Andrology, Reproductive Biomedicine Center, Royan Institute for Reproductive Biomedicine | Study Director |
| Eyed Jalil Hosseini, MD | Department of Andrology, Reproductive Biomedicine Center, Royan Institute for Reproductive Biomedicine | Study Director |
| Hani Department of Andrology, Reproductive Biomedicine Center, Roya, MSc | Department of Andrology, Reproductive Biomedicine Center, Royan Institute for Reproductive Biomedicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Royan Institute | Tehran | Iran |
Not provided
| Label | URL |
|---|---|
| Related Info | View source |
Not provided
Not provided
| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Placebo | Drug |
|
| 3 months |
| sperm motility | Evaluation the effect of ginger on sperm motility 3 months after oral administration. | 3 months |