Randomized Study of Spinal Anesthesia Compared With Traditional Epidural Anesthesia Concerning Peroperative and Postoperative Pain After Open Nephrectomy in Patients With Renal Cell Carcinoma

Randomized Study of Spinal Anesthesia Compared With Traditional Epidural Anesthesia Concerning Peroperative and Postoperative Pain After Open Nephrectomy in Patients With Renal Cell Carcinoma

The study aim to study whether spinal anesthesia (using: bupivacain, morfin och klonidin) can be better than epidural anesthesia during and after open surgery for renal cell carcinoma. Per- and postoperative pain after spinal anesthesia with klonidin can be reduced and, thus, shorten the hospital stay and rehabilitation of the patients.

Inclusion Criteria:

• all patients in ASA score I - III, planned to be treated with open radical nephrectomy or nephron-sparing surgery having renal cell carcinoma

Exclusion Criteria:

• patients in ASA score IV-V,
• patients with advanced tumour thrombus in vena cava inferior,
• patients with high risk for bleeding
• patients with previous chronic pain symptoms
• patients having drug abuse
• patients having cognitive deficiencies or dementia disease
• patients with any contraindication of either spinal or epidural anesthesia
• patients younger than 18 years and pregnant woman
• patients having a weight less than 45 kg or weight over 120 kg