Cocaine Opioid Oxytocin Option - Limited

Chronic Intranasal Oxytocin as an Adjunct to Methadone Maintenance Treatment in Patients With Co-occuring Opioid Use Disorder and Cocaine Use: A 2-week Pilot Study

This is a pilot feasibility study assessing the tolerability of chronic administration of intranasal oxytocin to patients receiving methadone at an opioid replacement clinic who are actively using cocaine.

Inclusion Criteria:

• Enrolled as a patient in the San Francisco General Hospital Opioid Treatment Outpatient Program
• Stable dose of methadone for at least the past two weeks
• At least one routine urine toxicology screen positive for cocaine in the past month

Exclusion Criteria:

• Positive urine pregnancy test
• Use of illicit drugs in the past month (with the exception of cocaine or cannabis)
• Currently meets Diagnostic and Statistical Manual-5 (DSM-V) criteria for severe major depressive disorder with suicidal thoughts or actions
• History of psychotic or moderate-severe alcohol use disorder as defined by DSM-V criteria
• Severe neuropsychological disorder, brain trauma, epilepsy
• Sensitivity to preservatives (in particular E 216, E 218 and chlorobutanol hemihydrate)
• Nasal obstruction, discharge, or bleeding
• Habitually drinks large volumes of water
• Taking testosterone, estrogen/progesterone supplement, or serotonin-1a receptor agonists/antagonists