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| Name | Class |
|---|---|
| Universität Tübingen | OTHER |
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To study concentrations of choline, its metabolites, and phospholipids in cord blood and remnants of clinically indicated blood samples
To collect cord plasma in preterm and term infants. To collect remnants of clinically indicated blood samples in parturients and hospitalized preterm infants during neonatal intensive care.
To determine concentrations of choline, its metabolites, and phospholipids by mass spectrometry.
To compare cord plasma concentrations with postnatal plasma concentrations.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| parturient | mother who had given birth within 48 hours of clinically indicated blood sampling |
| |
| healthy, non-pregnant, female volunteers | healthy, non-pregnant, female volunteers |
| |
| preterm infant | gestational age at birth < 37 weeks |
| |
| term infant | gestational age at birth >36 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| collection of remnant of clinically indicated blood sample | Other | collection of remnant of clinically indicated blood sample |
|
| Measure | Description | Time Frame |
|---|---|---|
| Concentration of choline in plasma | at times when a clinically indicated blood sample is taken before discharge home from the initial neonatal hospitalization (at a postnatal age of up to 4-5 months at the most in very preterm infants) |
| Measure | Description | Time Frame |
|---|---|---|
| concentrations of choline metabolites | at times when a clinically indicated blood sample is taken before discharge home from the initial neonatal hospitalization (at a postnatal age of up to 4-5 months at the most in very preterm infants) | |
| Concentrations of molecular species of phosphatidylcholine and phosphatidylethanolamine |
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Inclusion Criteria:
Exclusion Criteria:
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term and preterm neonates, parturients, non-pregnant females
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| Name | Affiliation | Role |
|---|---|---|
| Wolfgang Bernhard, MD, PhD | University Hospital Tuebingen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Tuebingen | Tübingen | 72076 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22961562 | Background | Bernhard W, Full A, Arand J, Maas C, Poets CF, Franz AR. Choline supply of preterm infants: assessment of dietary intake and pathophysiological considerations. Eur J Nutr. 2013 Apr;52(3):1269-78. doi: 10.1007/s00394-012-0438-x. Epub 2012 Sep 9. | |
| 25148882 | Derived | Bernhard W, Raith M, Kunze R, Koch V, Heni M, Maas C, Abele H, Poets CF, Franz AR. Choline concentrations are lower in postnatal plasma of preterm infants than in cord plasma. Eur J Nutr. 2015 Aug;54(5):733-41. doi: 10.1007/s00394-014-0751-7. Epub 2014 Aug 23. |
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| ID | Term |
|---|---|
| D047928 | Premature Birth |
| ID | Term |
|---|---|
| D007752 | Obstetric Labor, Premature |
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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| at times when a clinically indicated blood sample is taken before discharge home from the initial neonatal hospitalization (at a postnatal age of up to 4-5 months at the most in very preterm infants) |
| D000091642 | Urogenital Diseases |