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The purpose of this study is to find out what effect, if any, Low Frequency Therapeutic Ultrasound (LOTUS) has on kidney function in patients with chronic kidney disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Low Frequency Therapeutic Ultrasound | Experimental | Low Frequency Therapeutic Ultrasound (LOTUS) applied transcutaneously |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Low Frequency Therapeutic Ultrasound | Device | 29 kHz (kilohertz) low frequency therapeutic ultrasound delivered transcutaneously |
|
| Measure | Description | Time Frame |
|---|---|---|
| Glomerular Filtration Rate (GFR) | Absolute change in glomerular filtration rate, GFR, measured by Tc-99m DTPA (diethylenetriamine pentaacetic acid) imaging (Gates Method) in the treated kidney(s) from baseline to during LOTUS | Baseline and 15 minutes after start of Intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Percent change in GFR | Percent change in GFR in the treated kidney(s) from baseline to during LOTUS. | Baseline and 15 minutes after start of Intervention |
| Blood Pressure | Blood pressure is measured at baseline, during LOTUS intervention, and immediately after LOTUS intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Cutaneous Injury | Occurrence of cutaneous injury, such as erythema, blistering or rash occuring below the site of transducer placement | 5 minutes after LOTUS intervention |
| Heart rate | Heart rate will be measured at baseline, during LOTUS intervention, and immediately after LOTUS intervention has ended. |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Randall A Hawkins, MD | University of California, San Francisco | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Radiology and Biomedical Imaging, UCSF | San Francisco | California | 94107 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33313066 | Result | Dae MW, Liu KD, Solomon RJ, Gao DW, Stillson CA. Effect of Low-Frequency Therapeutic Ultrasound on Induction of Nitric Oxide in CKD: Potential to Prevent Acute Kidney Injury. Kidney Dis (Basel). 2020 Nov;6(6):453-460. doi: 10.1159/000509819. Epub 2020 Aug 21. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | May 31, 2022 | |
| Reset | Jun 23, 2022 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| May 31, 2022 | Jun 23, 2022 |
| ID | Term |
|---|---|
| D051436 | Renal Insufficiency, Chronic |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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| Baseline and 15 minutes after start of Intervention, and 5 minutes after end of intervention |
| Baseline and 15 minutes after start of Intervention, and 5 minutes after end of intervention. |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |