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The chances to achieve pregnancy after retrieving >15 oocytes are not good, probably because of bad effect on the endometrium (uterine inner lining). Therefore, in most such cases the investigators prefer to freeze all embryos, and transfer in a thaw cycle. With the introduction of oocyte vitrification (very fast cooling) technology, a new option emerged: to freeze un-fertilized eggs, to be fertilized and used later in a thaw cycle.
The purpose of this study is to compare the outcome of these two approaches.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| oocyte vitrification | Experimental | All retrieved mature oocytes will be vitrified. |
|
| embryo freezing | Active Comparator | All retrieved oocytes will be fertilized, and resulting embryos will be frozen. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| oocyte vitrification | Procedure |
| ||
| embryo freezing |
| Measure | Description | Time Frame |
|---|---|---|
| Fetal Heart Activity 1 Month Post Embryo Transfer | Fetal heart activity as demonsrated by vaginal ultrasound 1 month post embryo transfer | 1 month after embryo transfer |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| IVF Unit, Rambam medical Center | Haifa | Israel | 31096 | Israel |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21828116 | Background | Devroey P, Polyzos NP, Blockeel C. An OHSS-Free Clinic by segmentation of IVF treatment. Hum Reprod. 2011 Oct;26(10):2593-7. doi: 10.1093/humrep/der251. Epub 2011 Aug 9. |
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| ID | Title | Description |
|---|---|---|
| FG000 | Oocyte Vitrification | All retrieved mature oocytes will be vitrified. oocyte vitrification |
| FG001 | Embryo Freezing | All retrieved oocytes will be fertilized, and resulting embryos will be frozen. embryo freezing |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| ID | Title | Description |
|---|---|---|
| BG000 | Oocyte Vitrification | All retrieved mature oocytes will be vitrified. oocyte vitrification |
| BG001 | Embryo Freezing | All retrieved oocytes will be fertilized, and resulting embryos will be frozen. embryo freezing |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical | Count of Participants |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Fetal Heart Activity 1 Month Post Embryo Transfer | Fetal heart activity as demonsrated by vaginal ultrasound 1 month post embryo transfer | Posted | Number | participants with fetal heart activity | 1 month after embryo transfer |
|
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Oocyte Vitrification | All retrieved mature oocytes will be vitrified. oocyte vitrification |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Dr Shahar Kol , Director IVF Unit | Rambam health Care campus | 97247773232 | skol@rambam.health.gov.il |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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|
| BG002 | Total | Total of all reporting groups |
| Participants |
|
| Age, Continuous | Mean | Standard Deviation | years |
|
| Sex: Female, Male | Count of Participants | Participants |
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| Region of Enrollment | Number | participants |
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| Units |
|---|
| Counts |
|---|
| Participants |
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| 0 |
| 3 |
| 0 |
| 3 |
| EG001 | Embryo Freezing | All retrieved oocytes will be fertilized, and resulting embryos will be frozen. embryo freezing | 0 | 8 | 0 | 8 |
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